MICA Protein (Biotin,Fc-Avi Tag)
Quick Overview for MICA Protein (Biotin,Fc-Avi Tag) (ABIN7489079)
Target
See all MICA ProteinsProtein Type
Origin
Source
Purity
Grade
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Purification tag / Conjugate
- This MICA protein is labelled with Biotin,Fc-Avi Tag.
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Purpose
- Biotinylated Human MICA Protein, Fc,Avitag™ (MALS verified)
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Sequence
- Glu 24 - Gln 308
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Characteristics
- Biotinylated Human MICA Protein, Fc,Avitag is expressed from human 293 cells (HEK293). It contains AA Glu 24 - Gln 308 (Accession # Q29983-1).
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Endotoxin Level
- 1.0 EU per μg
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Comment
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This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™). (Biotin,Fc , Avi) The protein has a calculated MW of 61.0 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH 7.5
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Storage
- -20 °C
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Storage Comment
- -20°C
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- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
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Alternative Name
- MICA
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Background
- MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.
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Molecular Weight
- 61.0 kDa
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Pathways
- Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
Target
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