IL23A Protein (AA 20-189) (His tag)
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- Target See all IL23A Proteins
- IL23A (Interleukin 23, alpha subunit p19 (IL23A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 20-189
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL23A protein is labelled with His tag.
- Purpose
- Human IL-23 alpha & IL-12 beta Protein
- Sequence
- Arg20-Pro189 (IL-23 alpha) & Ile23-Ser328 (IL-12 beta)
- Specificity
- Uni-Prot: Q9NPF7 (IL-23 alpha), P29460 (IL-12 beta)
- Characteristics
- Recombinant Human IL-23 alpha & IL-12 beta Protein is expressed from HEK293 with His tag at the C-terminus.It contains Arg20-Pro189(IL-23 alpha) & Ile23-Ser328(IL-12 beta).
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product IL23A Protein
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Interleukin 23, alpha subunit p19 (IL23A) (AA 1-189) protein (GST tag)
IL23A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 23, alpha subunit p19 (IL23A) (AA 20-157) protein (His-IF2DI Tag)IL23A Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 23, alpha subunit p19 (IL23A) (AA 22-196) protein (His-Avi Tag,Biotin)IL23A Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Interleukin 23, alpha subunit p19 (IL23A) (AA 20-189) protein (His tag)Crystallography grade IL23A Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Interleukin 23, alpha subunit p19 (IL23A) (AA 22-196) protein (His tag)Crystallography grade IL23A Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- IL23A (Interleukin 23, alpha subunit p19 (IL23A))
- Alternative Name
- IL-23 alpha (IL23A Products)
- Synonyms
- IL-23 Protein, IL-23A Protein, IL23P19 Protein, P19 Protein, SGRF Protein, FIL1 Protein, FIL1(ZETA) Protein, FIL1Z Protein, IL-1F7 Protein, IL-1H Protein, IL-1H4 Protein, IL-1RP1 Protein, IL-37 Protein, IL1F7 Protein, IL1H4 Protein, IL1RP1 Protein, p19 Protein, il23p19 Protein, IL23 Protein, interleukin 23 subunit alpha Protein, interleukin 37 Protein, interleukin 23, alpha subunit p19 Protein, IL23A Protein, IL37 Protein, Il23a Protein
- Background
- The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn's disease (CD). Targeting this pathway has opened new avenues for therapeutic intervention. The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity.
- Molecular Weight
- 19.77 kDa (IL-23 alpha) and 34.7 kDa (IL-12 beta). Due to glycosylation, the protein migrates to 23 kDa (IL-23 alpha) and 40-50 kDa (IL-12 beta) based on Tris-Bis PAGE result.
- UniProt
- Q9NPF7
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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