MIF Protein (AA 2-115) (GST tag)
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- Target See all MIF Proteins
- MIF (Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor) (MIF))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-115
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MIF protein is labelled with GST tag.
- Sequence
- Pro2-Ala115
- Characteristics
- A DNA sequence encoding theHuman MIF protein (P14174) (Pro2-Ala115) was expressed with a N-GST.
- Purity
- >90 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product MIF Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- MIF (Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor) (MIF))
- Alternative Name
- MIF (MIF Products)
- Synonyms
- mif Protein, Mif Protein, gif Protein, glif Protein, mmif Protein, LOC100136498 Protein, LOC100284350 Protein, LOC100284546 Protein, GIF Protein, Glif Protein, GLIF Protein, MMIF Protein, macrophage migration inhibitory factor L homeolog Protein, macrophage migration inhibitory factor Protein, macrophage migration inhibitory factor (glycosylation-inhibiting factor) Protein, mif.L Protein, mif Protein, MIF Protein, Mif Protein, PHATRDRAFT_49660 Protein, LOC100136498 Protein, cl405_1 Protein, LOC100284546 Protein
- Background
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Background: Macrophage migration inhibitory factor (MIF) is an immunoregulatory cytokine, the effect of which on arresting random immune cell movement was recognized several decades ago. Despite its historic name, MIF also has a direct chemokine-like function and promotes cell recruitment. MIF is a ubiquitously expressed protein that plays a crucial role in many inflammatory and autoimmune disorders. Increasing evidence suggests that MIF also controls metabolic and inflammatory processes underlying the development of metabolic pathologies associated with obesity. Further research has shown that MIF plays a particularly critical part in cell cycle regulation and therefore in tumorigenesis as well. The significance of the role of MIF in a variety of both solid and hematologic tumors has been established. More recently, interest has increased in the role of MIF in the development of the central nervous system (CNS) tumors, in which it appears to influence cell cycle control. MIF contributes to malignant disease progression on several different levels. Both circulating and intracellular MIF protein levels are elevated in cancer patients and MIF expression reportedly correlates with stage, metastatic spread, and disease-free survival. Blockade of MIF bioactivity successfully inhibited tumor cell growth in vivo and in vitro. MIF plays important role in the pathogenesis of gastrointestinal, hepatic, and pancreatic disorders.
Synonym: Glycosylation-inhibiting factor,GIF,L-dopachrome isomerase,L-dopachrome tautomerase,Phenylpyruvate tautomerase
- Molecular Weight
- 38.3 kDa
- UniProt
- P14174
- Pathways
- Regulation of Systemic Arterial Blood Pressure by Hormones, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
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