Interleukin 35 Protein (IL35) (His tag)
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- Target See all Interleukin 35 (IL35) Proteins
- Interleukin 35 (IL35)
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Interleukin 35 protein is labelled with His tag.
- Sequence
- Arg21-Lys229&(GGGGS)3&Arg23-Ser219
- Characteristics
- A DNA sequence encoding theHuman IL-35 protein (Q14213&P29459) (Arg21-Lys229&(GGGGS)3&Arg23-Ser219) was expressed with a N-His.
- Purity
- >90 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product IL35 Protein
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Interleukin 35 (IL35) (AA 21-229), (AA 23-219) (Active) protein (His tag)
IL35 Origin: Human Host: Escherichia coli (E. coli) > 97 % AcA, CC Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- Interleukin 35 (IL35)
- Alternative Name
- IL-35 (IL35 Products)
- Background
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Background: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Synonym: IL-27 subunit beta,IL-27B,Epstein-Barr virus-induced gene 3 protein,EBV-induced gene 3 protein
- Molecular Weight
- 49.5 kDa
- UniProt
- Q14213, P29459
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