LILRA5 Protein (AA 42-268) (His tag)

Catalog No. ABIN7505590

Product Details

Target: LILRA5 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 (LILRA5))

Protein Type: Recombinant

Protein Characteristics: AA 42-268

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This LILRA5 protein is labelled with His tag.

Sequence: Gly42-Arg268

Characteristics: Recombinant Human LILRA5 Member 5 is produced by our Mammalian expression system and the target gene encoding Gly42-Arg268 is expressed with a 6His tag at the C-terminus.

Purity: >95 % as determined by reducing SDS-PAGE.

Endotoxin Level: <1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: LILRA5 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 (LILRA5))

Alternative Name: LILRA5 (LILRA5 Products)

Synonyms: CD85 Protein, CD85F Protein, ILT-11 Protein, ILT11 Protein, LILRB7 Protein, LIR-9 Protein, LIR9 Protein, E030017K20 Protein, EG232801 Protein, Gm4878 Protein, Lilrc1 Protein, leukocyte immunoglobulin like receptor A5 Protein, leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 Protein, LILRA5 Protein, Lilra5 Protein

Background:

Background: Leukocyte Immunoglobulin-like Receptor Subfamily A Member 5(LILRA5)is a member of the leukocyte immunoglobulin-like receptors (LILR), comprise a family of activating and inhibitory type immunoreceptors. LILRA5 consists of a 227 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 10 aa cytoplasmic tail. The ECD contains two Ig-like domains and the transmembrane segment contains a positively charged aspartic acid residue which may mediate its association with the signaling molecule, FcR common gamma chain. LILRA5 is expressed by monocytes, macrophages, and neutrophils. Cross-linking of LILRA5 on monocytes induces the expression of pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) as well as the anti-inflammatory IL-10. It can be detected in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Crosslink of ILT-11 on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses.

Synonym: Leukocyte immunoglobulin-like receptor subfamily A member 5, CD85 antigen-like family member F, Immunoglobulin-like transcript 11, ILT-11, Leukocyte immunoglobulin-like receptor 9, LIR-9, CD85f, LILRA5, LILRB7,CD85F,ILT11,LILRB7,LIR-9,LIR9

Molecular Weight: 26.1 kDa

UniProt: A6NI73