SCARB2 Protein (Fc Tag,His tag)

Catalog No. ABIN7533907

Product Details

Target: SCARB2 (Scavenger Receptor Class B, Member 2 (SCARB2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This SCARB2 protein is labelled with Fc Tag,His tag.

Purpose: Active Recombinant Human LIMP II/SCARB2/CD36L2 Protein

Sequence: RVFQKAVDQS IEKKIVLRNG TEAFDSWEKP PLPVYTQFYF FNVTNPEEIL RGETPRVEEV GPYTYRELRN KANIQFGDNG TTISAVSNKA YVFERDQSVG DPKIDLIRTL NIPVLTVIEW SQVHFLREII EAMLKAYQQK LFVTHTVDEL LWGYKDEILS LIHVFRPDIS PYFGLFYEKN GTNDGDYVFL TGEDSYLNFT KIVEWNGKTS LDWWITDKCN MINGTDGDSF HPLITKDEVL YVFPSDFCRS VYITFSDYES VQGLPAFRYK VPAEILANTS DNAGFCIPEG NCLGSGVLNV SICKNGAPII MSFPHFYQAD ERFVSAIEGM HPNQEDHETF VDINPLTGII LKAAKRFQIN IYVKKLDDFV ETGDIRTMVF PVMYLNESVH IDKETASRLK SMINTT

Specificity: Arg27-Thr432

Purity: > 97 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: < 0.1 EU/μg of the protein by LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA.Immobilized Human LDLR/LDL Receptor at 4μg/mL (100 μL/well) can bind Human SCARB2 with a linear range of 1.6-379 ng/mL.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Target Details

Target: SCARB2 (Scavenger Receptor Class B, Member 2 (SCARB2))

Alternative Name: LIMP II/SCARB2/CD36L2 (SCARB2 Products)

Synonyms: cd36l2 Protein, fi13c07 Protein, chunp6914 Protein, wu:fi13c07 Protein, SCARB2 Protein, scarb2 Protein, AMRF Protein, CD36L2 Protein, EPM4 Protein, HLGP85 Protein, LGP85 Protein, LIMP-2 Protein, LIMPII Protein, SR-BII Protein, 9330185J12Rik Protein, Cd36l2 Protein, MLGP85 Protein, LimpII Protein, scavenger receptor class B, member 2a Protein, scavenger receptor class B member 2 Protein, scavenger receptor class B, member 2 Protein, scarb2a Protein, SCARB2 Protein, scarb2 Protein, Scarb2 Protein

Background:

Description: The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Name: AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII,SCARB2,CD36L2,EPM4,HLGP85,LGP85,LIMP-2,LIMPII,SR-BII

Gene ID: 950

UniProt: Q14108