SERPING1 Protein (His tag)

Catalog No. ABIN7520498

Product Details

Target: SERPING1 (Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This SERPING1 protein is labelled with His tag.

Purpose: Recombinant Human Serpin G1/Plasma protease C1 inhibitor Protein

Sequence: MASRLTLLTL LLLLLAGDRA SSNPNATSSS SQDPESLQDR GEGKVATTVI SKMLFVEPIL EVSSLPTTNS TTNSATKITA NTTDEPTTQP TTEPTTQPTI QPTQPTTQLP TDSPTQPTTG SFCPGPVTLC SDLESHSTEA VLGDALVDFS LKLYHAFSAM KKVETNMAFS PFSIASLLTQ VLLGAGENTK TNLESILSYP KDFTCVHQAL KGFTTKGVTS VSQIFHSPDL AIRDTFVNAS RTLYSSSPRV LSNNSDANLE LINTWVAKNT NNKISRLLDS LPSDTRLVLL NAIYLSAKWK TTFDPKKTRM EPFHFKNSVI KVPMMNSKKY PVAHFIDQTL KAKVGQLQLS HNLSLVILVP QNLKHRLEDM EQALSPSVFK AIMEKLEMSK FQPTLLTLPR IKVTTSQDML SIMEKLEFFD FSYDLNLCGL TEDPDLQVSA MQHQTVLELT ETGVEAAAAS AISVARTLLV FEVQQPFLFV LWDQQHKFPV FMGRVYDPRA

Specificity: Met1-Ala500

Purity: > 95 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: < 0.1 EU/μg of the protein by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Target Details

Target: SERPING1 (Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1))

Alternative Name: Serpin G1/Plasma protease C1 inhibitor (SERPING1 Products)

Synonyms: fb64f02 Protein, im:7159527 Protein, si:dkeyp-110g5.2 Protein, wu:fb60c09 Protein, wu:fb62a08 Protein, wu:fb64f02 Protein, LOC100136072 Protein, C1-INH Protein, C1INH Protein, C1nh Protein, C1IN Protein, C1NH Protein, HAE1 Protein, HAE2 Protein, serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 Protein, C1 inhibitor Protein, serpin family G member 1 Protein, serine (or cysteine) peptidase inhibitor, clade G, member 1 Protein, serping1 Protein, LOC100136072 Protein, SERPING1 Protein, Serping1 Protein

Background:

Description: Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin).Serpin G1/C1 inhibitor is the physiological inhibitor of activated C1r and C1s and regulates activation of both the complement and contact systems. Deficiency of C1 inhibitor results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa. C1 inhibitor may prove useful in a variety of other diseases including septic shock, reperfusion injury, hyperacute transplant rejection, traumatic and hemorrhagic shock, and the increased vascular permeability associated with thermal injury, interleukin-2 therapy and cardiopulmonary bypass.

Name: SERPING1, C1IN, C1INH, C1NH, HAE1, HAE2, serpin family G member 1,C1IN,C1INH,C1NH,HAE1,HAE2

Gene ID: 710

UniProt: P05155

Pathways: Complement System