EPO Protein (AA 30-193) (Fc Tag)
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- Target See all EPO Proteins
- EPO (Erythropoietin (EPO))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 30-193
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Origin
- Human
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Source
- CHO Cells
- Purification tag / Conjugate
- This EPO protein is labelled with Fc Tag.
- Purpose
- EPO (human):Fc (human) (rec.) (non-lytic)
- Cross-Reactivity
- Human
- Characteristics
- The extracellular domain of human EPO (aa 30-193) is fused to the N-terminus of the Fc region of a mutant human IgG1.
- Purity
- >98 % (SDS-PAGE)
- Sterility
- Sterile filtered
- Endotoxin Level
- <0.06EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- Measured by the dose-dependant stimulation of human megakaryoblastic leukemia cells.
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Erythropoietin (EPO) (AA 28-193) (Active) protein
EPO Origin: Human Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active
Erythropoietin (EPO) (AA 1-193) protein (GST tag)EPO Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Erythropoietin (EPO) (Active) protein (His tag)EPO Origin: Mouse Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE. Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- EPO (Erythropoietin (EPO))
- Alternative Name
- EPO (EPO Products)
- Target Type
- Hormone
- Background
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Erythropoietin, Epoetin
Erythropoietin is the principal hormone involved in the regulation of erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells and the maintenance of a physiological level of circulating erythrocyte mass. It is a glycoprotein produced primarily by the kidney. The biological effects of EPO are mediated by the erythropoietin receptor (Epo R). Genetic variations in EPO is associated with susceptibility to microvascular complications of diabetes type 2 (MVCD2) (including diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease and diabetic neuropathy). It is used for the treatment of anemia and misused as a performance-enhancing drug in endurance athletes.
- NCBI Accession
- NP_000790
- Pathways
- JAK-STAT Signaling, Hormone Activity, Negative Regulation of intrinsic apoptotic Signaling, Negative Regulation of Transporter Activity
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