SARS-CoV-2 Spike Protein (AA 910-988)

Catalog No. ABIN7669678

This Recombinant SARS-CoV-2 Spike protein is produced in Escherichia coli (E. coli).

Quick Overview for SARS-CoV-2 Spike Protein (AA 910-988) (ABIN7669678)

Target: SARS-CoV-2 Spike

Protein Type: Recombinant

Biological Activity: Inactive

Origin: SARS Coronavirus-2 (SARS-CoV-2)

Source: Escherichia coli (E. coli)

Purity: > 95 %

Product Details

Protein Characteristics: AA 910-988

Purpose: Recombinant SARS-CoV-2 S Protein HR1

Sequence: Gly910-Glu988

Sterility: 0.2 μm filtered

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: SARS-CoV-2 Spike

Alternative Name: SARS-CoV-2 S

Target Type: Viral Protein

Background: The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, dipeptidyl peptidase-4, APN, aminopeptidase N, CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1, Sia, sialic acid, O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion, Defines the range of the hosts and specificity of the virus, Main component to bind with the neutralizing antibody, Key target for vaccine design, Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.,SARS-CoV-2 Spike,SARS-CoV-2 Spike Protein

Molecular Weight:

calculated_mw: 8.4 kDa

observed_mw: 8 kDa

UniProt: P0DTC2