ErbB2/Her2 Protein
Quick Overview for ErbB2/Her2 Protein (ABIN7849668)
Target
See all ErbB2/Her2 ProteinsProtein Type
Origin
Source
Application
Purity
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Purpose
- Native Human Epidermal growth factor receptor-2, HER2 Protein
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Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) (Active) protein (His-Avi Tag)
ErbB2/Her2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) (Active) protein (Biotin,His-Avi Tag)ErbB2/Her2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (Fc Tag)ErbB2/Her2 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) (Active) protein (His tag)ErbB2/Her2 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 489-630) protein (His-Avi Tag)ErbB2/Her2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 1-1255) protein (GST tag)ErbB2/Her2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (His tag)ErbB2/Her2 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 489-630) (Active) protein (Biotin,His-Avi Tag)ErbB2/Her2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) (Active) protein (His tag,Biotin)ErbB2/Her2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-510) (Active) protein (His tag)ErbB2/Her2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 10 mMPBS, pH 7.4.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Ship at 4°C.Upon receipt, aliquot and store at -20°C for long term. Avoid repeated freeze and thaw cycles.
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- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
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Alternative Name
- HER2
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Background
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Synonyms: erbB-2 isoform 2, HER2 receptor, Erbb2 protein, CerbB2, c erb B2, C erbB 2, C-erbB2, CD340, Erb B2, erbb2, HER 2, Her-2, HER 2/neu, HER2, Her2/neu, Herstatin, MLN 19, MLN19, NEU, NEU Proto Oncogene, Neuro Glioblastoma Derived Oncogene Homolog, NGL, p185 ErbB2, p185erbB2, Receptor Protein Tyrosine Kinase ErbB2 Precursor, Receptor tyrosine protein kinase erbB 2, TKR1, Tyrosine kinase type cell surface receptor HER2, v erb b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian), Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2.
Description: Purified human epidermalgrowth factor receptor-2, HER2 protein.
Background: Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. It is also frequently called HER2 (from human epidermal growth factor receptor 2) or HER2/neu. HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30 % of breast cancer patients.
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Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
Target
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