CREB1 Protein
Quick Overview for CREB1 Protein (ABIN7938676)
Target
See all CREB1 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant CREB1 protein
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cAMP Responsive Element Binding Protein 1 (CREB1) (AA 1-341) protein (GST tag)
CREB1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
cAMP Responsive Element Binding Protein 1 (CREB1) (AA 1-341) protein (His tag)CREB1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
cAMP Responsive Element Binding Protein 1 (CREB1) (AA 1-341), (full length) protein (His tag)CREB1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant CREB1 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
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Alternative Name
- CREB1
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Background
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Protein Background: CREB1 is a phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling.
Short Description: Recombinant CREB1 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_001358355.1) with an N-terminal FLAG tag. The molecular weight of CREB1 is 37.96 kDa.
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Pathways
- TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
Target
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