CDKN2C Protein

Catalog No. ABIN7938744

This Recombinant CDKN2C protein is expressed in Escherichia coli (E. coli).

Quick Overview for CDKN2C Protein (ABIN7938744)

Target: CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Product Details

Purpose: Recombinant CDKN2C protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant CDKN2C protein is supplied in 25 mM Tris pH 7.4, 300 mM NaCl, 10 % glycerol, 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C))

Alternative Name: CDKN2C

Background:

Protein Background: CDKN2C (Cyclin-dependent kinase 4 inhibitor C,also known as Cyclin-dependent kinase 6 inhibitor,p18- INK4c or p18-INK6) is a cyclin kinase inhibitors. Cell cycle regulatory proteins play a critical role in both normal cell growth and tumorigenesis, and the cyclin dependent kinases (CDKs) are the principle regulators of cell cycle progression , and thus are important candidates for therapeutic tumour suppressors. The CDKs, which are responsible for the phosphorylation of the retinoblastoma protein (pRb) and pRb related proteins, are in turn regulated by changes in cyclin levels, phosphorylation and the presence of cyclin kinase inhibitors (CKIs). Two classes of CKIs are present within mammalian cells . One class, the p21 family, consists of p21CIP1/WAF1, p27KIP1 and p57KIP2 which are general inhibitors of the G1S CDKs. Homology between family members is limited to a conserved amino-terminal 60-residue domain responsible for kinase binding and inhibition. The second class of CKIs, the INK4 (Inhibitor of CDK4) family is a group of ankyrin repeat proteins whose members p16INK4a, p15INK4b, p18INK4c and p19INK4d are specific inhibitors of cyclin D1/CDK4 or CDK6 complexes.CDKN2C/p18INK4c as a cyclin kinase inhibitors,Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

Short Description: Recombinant CDKN2C protein was expressed in E.colias the full length protein (accession number NP_001253.1) with an N-terminal 6xHis tag. The molecular weight of the protein is 20.06 kDa.

Aliases: Cyclin-dependent kinase 4 inhibitor C,also known as Cyclin-dependent kinase 6 inhibitor,p18- INK4c or p18-INK6

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases