JAK1 Protein (AA 438-1154)

Catalog No. ABIN7939210

This Recombinant JAK1 protein is expressed in Baculovirus infected Insect Cells.

Quick Overview for JAK1 Protein (AA 438-1154) (ABIN7939210)

Target: JAK1 (Janus Kinase 1 (JAK1))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Application: Functional Studies (Func), Activity Assay (AcA), Screening Assay (ScA)

Product Details

Protein Characteristics: AA 438-1154

Purpose: Recombinant JAK1 (438-1154) protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant JAK1 (438-1154) protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: JAK1 (Janus Kinase 1 (JAK1))

Alternative Name: JAK1

Background:

Protein Background: JAK1 (Janus Kinase 1) is a non-receptor tyrosine kinase which is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. JAK1 phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. It plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression It is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Diseases associated with JAK1 include Autoinflammation, Immune Dysregulation, And Eosinophilia and Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Jak1 Deficiency.

Short Description: Recombinant JAK1 (438-1154) protein that includes amino acids 438-1154 of human JAK1 protein (accession number NP_001307852.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 83.6 kDa

Aliases: Janus Kinase 1

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response