MECP2 Protein (AA 80-166)
Quick Overview for MECP2 Protein (AA 80-166) (ABIN7939270)
Target
See all MECP2 ProteinsProtein Type
Origin
Source
Application
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Protein Characteristics
- AA 80-166
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Purpose
- Recombinant MECP2 (80-166) protein
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Methyl CpG Binding Protein 2 (MECP2) (AA 1-486) protein (GST tag)
MECP2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Methyl CpG Binding Protein 2 (MECP2) (AA 81-170) protein (GST tag)MECP2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Methyl CpG Binding Protein 2 (MECP2) (AA 329-486) protein (His tag)MECP2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant MECP2 (80-166) protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- MECP2 (Methyl CpG Binding Protein 2 (MECP2))
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Alternative Name
- MECP2
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Background
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Protein Background: MECP2 (Methyl-CpG-binding protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5 methylcytosine (5mC).
Short Description: Recombinant MECP2 (80-166) protein that includes amino acids 80-166 of human MECP2 protein (accession number NP_004983.1) was expressed in E. coli cells with an N-terminal 6xHis tag. The molecular weight of the protein is 12.19 kDa.
Aliases: Methyl-CpG-binding protein 2, MeCp-2 Protein, MRX16, MRX79, RTT
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Pathways
- Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane
Target
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