JNK2 Protein

Catalog No. ABIN7939325

This Recombinant JNK2 protein is produced in Escherichia coli (E. coli).

Quick Overview for JNK2 Protein (ABIN7939325)

Target: JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: Functional Studies (Func), Activity Assay (AcA), Screening Assay (ScA)

Product Details

Purpose: Recombinant MAPK9 (JNK2) protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant MAPK9 (JNK2) protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))

Alternative Name: MAPK9

Background:

Protein Background: MAPK9 (Mitogen-activated protein kinase 9) also know as JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, p54a, p54aSAPK, PRKM9, SAPK and SAPK1a. MAPK9 is a serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/cJun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2.

Short Description: Recombinant MAPK9 (JNK2) protein that includes full length of human MAPK9 protein (accession number NP_001351537.1) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 50.3 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.

Aliases: JNK-55, JNK2, JNK2A, JNK2AKPHA, JNK2B, JNK2BETA, p54a, p54aSAPK, PRKM9, SAPK, SAPK1a

Pathways: MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteins