MBP Protein

Catalog No. ABIN7939351

Recombinant MBP protein expressed in Escherichia coli (E. coli).

Quick Overview for MBP Protein (ABIN7939351)

Target: MBP (Myelin Basic Protein (MBP))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Product Details

Purpose: Recombinant Myelin Basic Protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant Myelin Basic protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: MBP (Myelin Basic Protein (MBP))

Alternative Name: Myelin Basic

Background:

Protein Background: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

Short Description: Recombinant Myelin Basic protein that includes full length of human MBP protein (accession number NP_001020252.1 ) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 23.79 kDa. The purity of the protein is ≥ 90 % by SDS-PAGE.