ERBB3 Protein (AA 665-1342)
Quick Overview for ERBB3 Protein (AA 665-1342) (ABIN7939510)
Target
See all ERBB3 ProteinsProtein Type
Origin
Source
Application
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Protein Characteristics
- AA 665-1342
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Purpose
- Recombinant ErbB3 / HER3 (665-1342) protein
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Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 20-643) protein (His-Avi Tag)
ERBB3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 20-643) protein (His tag)ERBB3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, AM, ADA, IA
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 20-643) (Active) protein (Biotin,His-Avi Tag)ERBB3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 20-643) (Active) protein (hFc Tag)ERBB3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 20-641) (Active) protein (His tag)ERBB3 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 21-331) protein (GST tag)ERBB3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (Active) protein (His tag)ERBB3 Origin: Mouse Host: HEK-293 Cells Recombinant > 93 % as determined by SDS-PAGE Active
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) protein (Biotin,His-Avi Tag)ERBB3 Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 1005-1230) protein (His tag)ERBB3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 544-643) protein (mFc Tag)ERBB3 Origin: Human Host: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant ErbB3 / HER3 (665-1342) protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
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Alternative Name
- ErbB3 & HER3
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Background
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Protein Background: ErbB3 (Receptor tyrosine-protein kinase erbB-3) is a tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it, ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
Short Description: Recombinant ErbB3 / HER3 (665-1342) protein that includes amino acids 665-1342 of human ErbB3 protein (accession number NP_001973.2) was expressed in a baculovirus expression system and contains an N-terminal FLAG tag. The molecular weight of the protein is 76.52 kDa.
Aliases: Receptor tyrosine protein kinase erbB-3, HER3, Oncogene Homolog 3, LCCS2, FERLK, LCCS2, FERLK, ErbB-3, ErbB3-S, EC 2.7.10
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Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Target
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