RPS6KA2 Protein
Quick Overview for RPS6KA2 Protein (ABIN7939515)
Target
See all RPS6KA2 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant RPS6KA2/RSK3 protein
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Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2) (AA 1-733) protein (His tag)
custom-made RPS6KA2 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2) (AA 1-733) protein (His tag)custom-made RPS6KA2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2) (AA 1-733) protein (GST tag)RPS6KA2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2) (Active) protein (GST tag)RPS6KA2 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 84 % as determined by reducing SDS-PAGE. Active
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2) (AA 66-311) protein (His-IF2DI Tag)RPS6KA2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)RPS6KA2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Buffer
- Recombinant RPS6KA2 / RSK3 protein is supplied at a concentration in 25 mM HEPES, NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))
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Alternative Name
- RPS6KA2 & RSK3
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Background
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Protein Background: RPS6KA2 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. RPS6KA2 acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. Diseases associated with RPS6KA2 include Coffin-Lowry Syndrome and Dyskeratosis Congenita, Autosomal Dominant 3.
Short Description: Recombinant RPS6KA2 / RSK3 protein was expressed in baculovirus expression system as the full-length protein (accession number NP_066958.2) with a N-terminal FLAG tag. The molecular weight of the protein is 84.5 kDa.
Aliases: ribosomal S6 kinase
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Pathways
- MAPK Signaling, Neurotrophin Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Activation of Innate immune Response, Toll-Like Receptors Cascades
Target
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