RPS6KA2 Protein (GST tag)

Catalog No. ABIN7317081

Product Details

Target: RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This RPS6KA2 protein is labelled with GST tag.

Purpose: Recombinant Human RSK3/RPS6KA2 Protein (GST Tag)(Active)

Sequence: Met 1-Leu 733

Characteristics: A DNA sequence encoding the human RPS6KA2 isoform 1 (Q15349-1) (Met 1-Leu 733) was fused with the GST tag at the N-terminus.

Purity: > 84 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 41 nmol/min/mg using synthetic RSK peptide (KRRRLSSLRA) as substrate.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.0, 20 mM GSH

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))

Alternative Name: RSK3/RPS6KA2 (RPS6KA2 Products)

Synonyms: HU-2 Protein, MAPKAPK1C Protein, RSK Protein, RSK3 Protein, S6K-alpha Protein, S6K-alpha2 Protein, p90-RSK3 Protein, pp90RSK3 Protein, 90kDa Protein, D17Wsu134e Protein, Rps6ka-rs1 Protein, Rsk3 Protein, p90rsk Protein, pp90rsk Protein, ribosomal protein S6 kinase A2 Protein, ribosomal protein S6 kinase, polypeptide 2 Protein, Rps6ka2 Protein, RPS6KA2 Protein

Background:

Background: Ribosomal protein S6 kinase alpha-2, also known as 90 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 arrest, increased apoptosis, reduced levels of phosphorylated extracellular signal-regulated kinase and altered other cell cycle proteins. RPS6KA2 / RSK-3 contains one AGC-kinase C-terminal domain and two protein kinase domains. It forms a complex with either ERK1 or ERK2 in quiescent cells. It transiently dissociates following mitogenic stimulation. RPS6KA2 / RSK-3 is a serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 are involved in several pathways central to the carcinogenic process, including regulation of cell growth, insulin, and inflammation. 

Synonym: HU-2;MAPKAPK1C;p90-RSK3;pp90RSK3;RSK;RSK3;S6K-alpha;S6K-alpha2

Molecular Weight: 110 kDa

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Activation of Innate immune Response, Toll-Like Receptors Cascades