STAT5B Protein
Quick Overview for STAT5B Protein (ABIN7939574)
Target
See all STAT5B ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant STAT5B protein
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Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-786) protein (His tag)
custom-made STAT5B Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-787) protein (His tag)custom-made STAT5B Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-390) protein (GST tag)STAT5B Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-321) protein (His-IF2DI Tag)STAT5B Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant STAT5B protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
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Alternative Name
- STAT5B
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Background
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Protein Background: Signal transducers and activators of transcription 5 (STAT5a and STAT5b) are highly homologous proteins that are encoded by 2 separate genes and are activated by Janus-activated kinases (JAK) downstream of cytokine receptors. STAT5 proteins are activated by a wide variety of hematopoietic and nonhematopoietic cytokines and growth factors, all of which use the JAK-STAT signalling pathway as their main mode of signal transduction. STAT5 proteins critically regulate vital cellular functions such as proliferation, differentiation, and survival.
Short Description: Recombinant STAT5B protein was expressed in a baculovirus expression system as the full length protein (accession number NP_036580.2) with an N-terminal FLAG tag. The molecular weight of the protein is 91.14 kDa
Aliases: Transcription Factor STAT5B, GHISID2, STAT5
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Pathways
- JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
Target
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