SMAD2 Protein
Quick Overview for SMAD2 Protein (ABIN7939588)
Target
See all SMAD2 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant SMAD2 protein
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SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 181-280) protein (GST tag)
SMAD2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
SMAD, Mothers Against DPP Homolog 2 (SMAD2) protein (GST tag,His tag)SMAD2 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE
SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 2-467) protein (His-IF2DI Tag)SMAD2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 1-467) protein (His tag)SMAD2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
SMAD, Mothers Against DPP Homolog 2 (SMAD2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)SMAD2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant SMAD2 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
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Alternative Name
- SMAD2
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Background
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Protein Background: The transforming growth factor-beta (TGF-b) superfamily signaling controls a wide variety of biological processes from development to pathogenesis primarily through intracellular Smad proteins. Smads are structurally and functionally grouped into three subfamilies: five receptor-activated Smads (R-Smads), one common Smad and two inhibitory Smads. Of R-Smads, Smad2 and Smad3 (Smad2/3 thereafter for simplicity) transduce activin and TGF-b signals, whereas Smad1, Smad5 and Smad8 transduce signals from the BMP/GDF (Bone Morphogenetic Proteins/ Growth Differentiation Factor) family. SMAD2 is key intracellular signal transducers for TGF-b signaling and their transcriptional activities are controlled through reversible phosphorylation and nucleocytoplasmic shuttling.
Short Description: Recombinant SMAD2 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_005892.1) with an N-terminal FLAG tag. The molecular weight of SMAD1 is 53.58 kDa.
Aliases: SMAD family member 2, MADR2, MADH2, Mothers Against Decapentaplegic Homolog 2, HMAD-2
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Pathways
- Cell Division Cycle, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
Target
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