VEGFR2/CD309 Protein (AA 789-1356)

Catalog No. ABIN7939743

This Recombinant VEGFR2/CD309 protein is produced in Baculovirus infected Insect Cells.

Quick Overview for VEGFR2/CD309 Protein (AA 789-1356) (ABIN7939743)

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Application: Functional Studies (Func), Screening Assay (ScA), Activity Assay (AcA)

Product Details

Protein Characteristics: AA 789-1356

Purpose: Recombinant KDR / VEGFR2 (789-1356) protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant KDR / VEGFR2 (789-1356) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Alternative Name: KDR & VEGFR2

Background:

Protein Background: KDR (Kinase Insert Domain Receptor) is a tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD and plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. KDR promotes proliferation, survival, migration and differentiation of endothelial cells and promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Diseases associated with KDR is infantile capillary hemangiomas.

Short Description: Recombinant KDR / VEGFR2 (789-1356) protein that includes amino acids 789-1356 of human KDR protein (accession number NP_002244.1) with a N-terminal FLAG tag. The molecular weight of the protein is 64.4 kDa.

Aliases: VEGFR2, Flk-1

Pathways: RTK Signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling