YAP1 Protein
Quick Overview for YAP1 Protein (ABIN7939761)
Target
See all YAP1 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant YAP1 protein
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Yes-Associated Protein 1 (YAP1) (AA 1-504) protein (GST tag)
YAP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Yes-Associated Protein 1 (YAP1) (AA 53-161) protein (GST tag)YAP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Yes-Associated Protein 1 (YAP1) (AA 1-504) protein (His tag)YAP1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining. ScA, AM, ADA, IA
Yes-Associated Protein 1 (YAP1) (AA 350-504) protein (His tag)YAP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Yes-Associated Protein 1 (YAP1) (AA 1-504), (full length) protein (His tag)YAP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
Yes-Associated Protein 1 (YAP1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)YAP1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant YAP1 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- YAP1 (Yes-Associated Protein 1 (YAP1))
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Alternative Name
- YAP1
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Background
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Protein Background: YAP1 is a transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes.
Short Description: Recombinant YAP1 protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_001181973.1) with an N-terminal FLAG tag. The molecular weight of YAP1 is 54.04 kDa.
Aliases: YAP65, YAP-1, Transcriptional Coactivator YAP1, Yes Associated Protein 1, COB1, YAP2, YAP, YKI
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Pathways
- MAPK Signaling, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha
Target
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