PSMD10 Protein (AA 1-226)
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- Target See all PSMD10 Proteins
- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-226
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Sequence
- MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG
- Characteristics
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Purified recombinant Human Gankyrin protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher. - Purity
- > 95 % pure
- Top Product
- Discover our top product PSMD10 Protein
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- Application Notes
- Gankyrin protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Supplied as a liquid in PBS, pH 7.4, containing 10 % glycerol.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- RT/-20 °C
- Storage Comment
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- Target
- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
- Alternative Name
- Gankyrin (PSMD10 Products)
- Synonyms
- gankyrin Protein, zgc:109707 Protein, dJ889N15.2 Protein, p28 Protein, p28(GANK) Protein, AW554874 Protein, p28Gank Protein, proteasome 26S subunit, non-ATPase 10 Protein, proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Protein, psmd10 Protein, PSMD10 Protein, Psmd10 Protein
- Background
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Gankyrin is an oncoprotein commonly overexpressed in most hepatocellular carcinomas. Gankyrin interacts with S6 ATPase of the 19S regulatory particle of the 26S proteasome. It is known to play a role in the regulation of the phosphorylation of the retinoblastoma protein by CDK4, and to enhance the ubiquitinylation of p53 by MDM2. Gankyrin consists of 7 ankyrin repeats and is structurally similar to I kappa Bs. Recombinant human Gankyrin was expressed in E. coli and purified by conventional chromatography techniques.
Alternative Names: Gankyrin protein, 26S proteasome regulatory subunit p28 protein, 26S proteasome non-ATPase regulatory subunit 10 protein, PSMD10., proteasome 26S subunit non ATPase 10 (PSMD10) isoform 1 protein, ankyrin repeat protein p28 protein - Molecular Weight
- 24.4 kDa (226 AA)
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway
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