GDF15 Protein

Catalog No. ABIN935652

This Recombinant GDF15 protein is expressed in CHO Cells.

Quick Overview for GDF15 Protein (ABIN935652)

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: CHO Cells

Purity: > 98 % pure

Product Details

Sequence: ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI

Characteristics: Purified recombinant Human GDF15 protein
Expression System: Cell culture
Bioactivity: Determined by a cell inhibition assay using DU-145 cells. The expected ED50 for this effect is 1.0-2.0 µg/mL.

Endotoxin Level: < 0.1 ng per µg (1 EU/µg).

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.

Buffer: Lyophilized from 10 mM Sodium Citrate, pH 3.0.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Target Details

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Alternative Name: GDF15

Background: GDF-15 belongs to the TGF beta cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.
Alternative Names: GDF 15, GDF 15 protein, GDF15, GDF-15 protein, GDF-15, GDF-15 protein, Prostate differentiation factor protein, MIC-1 protein, Placental TGFbeta protein

Pathways: SARS-CoV-2 Protein Interactome