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PTP4A3 Products

(Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3))
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. [provided by RefSeq, Jul 2008].

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Featured PTP4A3 Categories

PTP4A3 Antibodies

High quality antibodies with extensive validation data.

PTP4A3 ELISA Kits

Reliable ELISA kits for a wide range of species.

PTP4A3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PTP4A3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, ICC, IP
Validations
  • (3)
Cat. No. ABIN7435550
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, ICC, IF
Validations
  • (3)
Cat. No. ABIN6264515
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (3)
Cat. No. ABIN1682391
Quantity 100 μg
Datasheet Datasheet

Recommended PTP4A3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958954
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4884249
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6384905
Quantity 96 tests
Datasheet Datasheet

Recommended PTP4A3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (2)
Cat. No. ABIN7275479
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN666667
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316805
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our PTP4A3 products

Gari, DeGala, Ray, Lucia, Lambert: "PRL-3 engages the focal adhesion pathway in triple-negative breast cancer cells to alter actin structure and substrate adhesion properties critical for cell migration and invasion." in: Cancer letters, Vol. 380, Issue 2, pp. 505-12, (2016) (PubMed).

Gari, DeGala, Lucia, Lambert: "Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth." in: Oncogenesis, Vol. 5, Issue 8, pp. e255, (2016) (PubMed).

Ye, Al-Aidaroos, Park, Yuen, Zhang, Gupta, Lin, Shen, Zeng: "PRL-3 activates mTORC1 in Cancer Progression." in: Scientific reports, Vol. 5, pp. 17046, (2015) (PubMed).

Fromont, Godet, Peyret, Irani, Celhay, Rozet, Cathelineau, Cussenot: "8q24 amplification is associated with Myc expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy." in: Human pathology, Vol. 44, Issue 8, pp. 1617-23, (2013) (PubMed).

Fagerli, Holt, Holien, Vaatsveen, Zhan, Egeberg, Barlogie, Waage, Aarset, Dai, Shaughnessy, Sundan, Børset: "Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells." in: Blood, Vol. 111, Issue 2, pp. 806-15, (2008) (PubMed).

Kozlov, Cheng, Ziomek, Banville, Gehring, Ekiel: "Structural insights into molecular function of the metastasis-associated phosphatase PRL-3." in: The Journal of biological chemistry, Vol. 279, Issue 12, pp. 11882-9, (2004) (PubMed).

Kim, Song, Jee, Sheen, Lee, Lee, Ro, Cho, Lee, Yamazaki, Jeon, Cheong: "Structure of human PRL-3, the phosphatase associated with cancer metastasis." in: FEBS letters, Vol. 565, Issue 1-3, pp. 181-7, (2004) (PubMed).

Wu, Zeng, Zhang, Zhao, Sha, Ge, Zhang, Gao, Xu: "Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells." in: The American journal of pathology, Vol. 164, Issue 6, pp. 2039-54, (2004) (PubMed).

Kato, Semba, Miskad, Seo, Kasuga, Yokozaki: "High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 21, pp. 7318-28, (2004) (PubMed).

Bardelli, Saha, Sager, Romans, Xin, Markowitz, Lengauer, Velculescu, Kinzler, Vogelstein: "PRL-3 expression in metastatic cancers." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 9, Issue 15, pp. 5607-15, (2003) (PubMed).

Synonyms and alternative names related to PTP4A3

protein tyrosine phosphatase type IVA, member 3 (PTP4A3), protein tyrosine phosphatase type IVA, member 3 (ptp4a3), protein tyrosine phosphatase type IVA, member 3 L homeolog (ptp4a3.L), protein tyrosine phosphatase 4a3 (Ptp4a3), protein tyrosine phosphatase type IVA, member 3 (Ptp4a3), AV088979, pPtp4a3, PRL-3, prl-3, Prl-3, PRL-R, PRL3, prl3, PTP4A3, ptpcaax3, wu:fc54b05, wu:fv52d11, zgc:77109

Protein level used designations for PTP4A3

  • potentially prenylated protein tyrosine phosphatase
  • protein tyrosine phosphatase type IVA 3
  • protein-tyrosine phosphatase 4a3
  • protein-tyrosine phosphatase of regenerating liver 3
  • PRL-3
  • fc54b05
  • fv52d11
  • xPRL-3
  • protein tyrosine phosphatase type IVA, member 3
  • protein tyrosine phosphatase 4a3
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