PUMA Proteins
(BCL2 Binding Component 3 (BBC3))
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
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13 results
custom-made
BBC3
Origin: Human
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
BBC3
Origin: Human
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
BBC3
Origin: Mouse
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
BBC3
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
Greater than 90 % by SDS-PAGE gel analyses
WB, ELISA
1 image
BBC3
Origin: Human
Host: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
1 reference
BBC3
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 90 % as determined by reducing SDS-PAGE.
Imm
BBC3
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
WB, SDS, ELISA
BBC3
Origin: Rat
Host: Escherichia coli (E. coli)
Recombinant
> 95 %
WB, SDS, Imm, PC
custom-made
BBC3
Origin: Mouse
Host: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
BBC3
Origin: Human
Host: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
BBC3
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
~95 %
WB, ELISA, MS
1 image
BBC3
Origin: Human
Host: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
Latest Publications for our PUMA Proteins
: "HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells." in: PLoS ONE, Vol. 8, Issue 11, pp. e78836, (2013) (PubMed).Aliases for PUMA Proteins
BCL2 binding component 3 (BBC3) ProteinsBcl-2 binding component 3 (Bbc3) Proteins
BCL2 binding component 3 (Bbc3) Proteins
BCL2 binding component 3 (bbc3) Proteins
BBC3 Proteins
JFY-1 Proteins
JFY1 Proteins
Puma Proteins
PUMA Proteins
PUMA/JFY1 Proteins
Did you look for something else?
- PUM2 Proteins
- PUM1 Proteins
- PTX3 Proteins
- PTTG1IP Proteins
- PTTG1 Proteins
- PTS Proteins
- PTRHD1 Proteins
- PTRH2 Proteins
- PTRF Proteins
- PTPRU Proteins
- PTPRS Proteins
- PTPRR Proteins
- PTPRQ Proteins
- PTPRO Proteins
- PTPRN2 Proteins
- PTPRN Proteins
- PTPRM Proteins
- PTPRK Proteins
- PTPRH Proteins
- PTPRG Proteins
- PURA Proteins
- Purine Nucleoside Phosphorylase Proteins
- Purine-Rich Element Binding Protein B Proteins
- Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Proteins
- Purinergic Receptor P2Y, G-Protein Coupled, 13 Proteins
- PUS1 Proteins
- PUS10 Proteins
- PUS3 Proteins
- PUSL1 Proteins
- PVALB Proteins
- PVRIG Proteins
- PVRL1 Proteins
- PVRL2 Proteins
- PVRL3 Proteins
- PVRL4 Proteins
- PWP1 Proteins
- PXK Proteins
- PYCARD Proteins
- PYCR1 Proteins
- PYCR2 Proteins
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