Development of monoclonal antibodies against disseminating Klebsiella pneumoniae
NIH View original grantABSTRACT/SUMMARY Klebsiella pneumoniae (Kpn) is a primary causative agent of healthcare-associated infections, posing a significant global health burden. Bloodstream Kpn infections are of particular concern as they contribute to high patient mortality. Kpn colonizes the gastrointestinal (GI) tract of both healthy and immunocompromised individuals. Kpn can translocate from the gut and enter the bloodstream, where it is typically cleared in immunocompetent individuals. In immunocompromised patient
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