|Antigen||BAI1-Associated Protein 2-Like-1 (BAIAP2L1) Antibodies|
|Epitope||AA 1-226 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
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Species reactivity (expected):Mouse (94 %) and Rat (94 %).
Species reactivity (tested):Human.
|Immunogen||Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 226 of BAIAP2L1 Genename: BAIAP2L1|
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|Alternative Name||BAIAP2L1 (BAIAP2L1 Antibody Abstract)|
|Background||This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq].Synonyms: BAI1-associated protein 2-like 1, Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1, IRTKS, Insulin receptor tyrosine kinase substrate|
|Gene ID||55971, 9606|
|Pathways||Regulation of Actin Filament Polymerization|
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Western blot: 1/500-1/3000. Positive Controls: 293T, A431, HeLa, HepG2. Immunofluorescence: 1/100-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
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|Buffer||0.1 M Tris, 0.1 M Glycine, 10 % Glycerol ( pH 7), 0.01 % Thimerosal|
|Precaution of Use||This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage Comment||Store the antibody undiluted (in aliquots) at -20 °C.|