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we found that Dlg1 was expressed at different stages of oocyte development. at the germinal vesicle stage, Dlg1 was present in the cytoplasm, prominently surrounding the germinal vesicle membrane. During maturation, Dlg1 became highly polarised by associating with the spindle and formed characteristic crescent (show SFRP5 Proteins)-shaped accumulations under the cortex.
Adrenergic modulation of Kv1.1 (show KCNA2 Proteins) was mediated by the signaling scaffold SAP97, which, through direct protein-protein interactions, escorts beta2 signaling to remove Kv1.1 (show KCNA2 Proteins) from the dendrite surface. This process promoted spike timing-dependent long-term synaptic potentiation at mouse hippocampal excitatory synapses.
that Pten, through the Dlg1-binding ability of its PDZ-binding domain , accumulates phosphorylated Eg5 (show KIF11 Proteins) at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes
Kif13b also negatively regulates Dlg1 stability in oligodendrocytes, in which Dlg1, in contrast to Schwann cells, enhances AKT (show AKT1 Proteins) activation and promotes myelination
Dlg1 regulates p38 (show CRK Proteins)-dependent proinflammatory cytokine production.
phenotypes of Dlg1-/- mice involving cellular disorganization and insufficient tissue elongation strongly suggest a defect in the convergent extension movements
Loss of Dlg1 confers strong predisposition to the development of pediatric B-ALL in a murine model.
data indicate that the surface expression and function of EAAT2b can be rapidly modulated through the disruption of its interaction with DLG1 by CaMKII (show CAMK2G Proteins) activation.
Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling.
lack of the Dlg1 gene induces a decrease in apoptotic epithelial cell death and the persistence of the common nephric duct, which result in a dysfunctional vesicoureteral junction and cause megaureter or hydronephrosis through vesicoureteral reflux
the increased expression of DLG1 may be predictive of an unfavorable prognosis in colorectal cancer.
By fluorescence resonance energy transfer (FRET), we detected the direct binding of Tax (show CNTN2 Proteins) to DLG1 within the cell. The interaction specifically affects the cellular distribution of not only DLG1, but also Tax (show CNTN2 Proteins). The aggregates distribute into the Golgi apparatus in spatial association with the microtubule-organizing center (MTOC).
These data support diverging presynaptic and postsynaptic roles of SAP97 N-terminal isoforms in synapse maturation and plasticity
Single nucleotide polymorphism in DLG1 gene is associated with schizophrenia.
Low expression of DLG1 is associated with Crohn's disease.
BAIAP2 (show BAIAP2 Proteins) is a candidate gene for mediating dendritic spine density abnormalities in schizophrenia. Data suggest that altered DNA methylation (show HELLS Proteins) in schizophrenia may be a mechanism for schizophrenia-related dendritic spine density reductions.
Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt/beta-catenin signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta phosphorylation.
Results suggest that discs large (show DLG4 Proteins) tumour suppressor (DLG1) expression may have an important role in the progression of early dysplastic cervical lesions, giving prognostic information.
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia was identified.
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.
discs, large homolog 1 (Drosophila)
, synapse-associated protein 97
, disks large homolog 1
, Drosophila discs-large tumor suppressor homologue (synapse associated protein)
, embryo-dlg/synapse-associated protein 97
, presynaptic protein SAP97