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While Slit1 and Robo2 (show ROBO2 Proteins) are only expressed in peripheral axons and their cell bodies, Slit2 (show SLIT2 Proteins), Slit3 (show SLIT3 Proteins) and Robo1 (show ROBO1 Proteins) are also expressed in satellite cells of the dorsal root ganglion, Schwann cells and fibroblasts of peripheral nerves.
Data indicate the roles of Slit1/Robo1 (show ROBO1 Proteins) and Netrin1/DCC (show DCC Proteins) signals in positioning motor neuron cell bodies.
a role for Slit1 in corpus callosum development
Robo-2 (show ROBO2 Proteins)-mediated targeting of P2 axons along the dorsoventral axis of the OB is controlled by Slit-1 expression
This study demonistrated that production of IPCs is enhanced in Robo1 (show ROBO1 Proteins)/2 and Slit1/2 mutants, suggesting that Slit/Robo signaling modulates the transition between primary and intermediate progenitors.
Disruption of either the Robo1 (show ROBO1 Proteins) or Slit1 genes accelerates progression of thalamocortical axons in vivo.
Slit1 has a dual context-dependent role in thalamocortical axons formation
Robo1 (show ROBO1 Proteins) and Robo2 (show ROBO2 Proteins) are expressed in the nucleus origin of the tract of the postoptic commissure TPOC (nTPOC), while Slit expression domains flank the TPOC trajectory.
Nkx2.9 controls SACMN axon exit from the mammalian spinal cord by regulating Robo-Slit signaling
Data show that only Nck2 (show NCK2 Proteins) is required for the Slit1-induced changes in cortical neuron morphology in vitro.
evidence showing that Slit1 and Slit2 proteins are selective inhibitors and repellents for dorsally projecting, but not for ventrally projecting, cranial motor axons
In fetal and embryonic stem cell cultures Slit-1 inhibited neurite outgrowth.
Slits are negative regulators of Sdf1 (show CXCL12 Proteins) and Cxcr4 (show CXCR4 Proteins) in breast cancer cells.
A specific signaling pathway downstream of Fgfr1 controls in a cell-autonomous manner slit1 forebrain expression and identifies a specific growth factor receptor for in vivo control of the expression of a key embryonic axon guidance cue.
Slit acts via Robo2 (show ROBO2 Proteins) in dendrites as a branching/growth factor but not in guidance, while Robo2 (show ROBO2 Proteins) and Robo3 (show ROBO3 Proteins) function in concert in axons to mediate axonal interactions and respond to Slits as guidance factors
These results suggested that the role of SLIT1 is altered postnatally and that this is particularly important for prefrontal connectivity in the Old World monkey cortex.
During motor axon regeneration, col4a5 (show COL4A1 Proteins) destabilizes axons probing inappropriate trajectories to ensure target-selective regeneration, possible through slit1a.
Genetic analysis showed that Caspase-3 (show CASP3 Proteins), Caspase-9 (show CASP9 Proteins), and p38 MAPK (show MAPK14 Proteins) interacted with Slit1a-Robo2 (show ROBO2 Proteins) signaling.
Study shows that the laminar specificity of retinotectal connections does not depend on self-sorting interactions among retinal ganglion cells axons; rather, tectum-derived Slit1, signaling through axonal Robo2 (show ROBO2 Proteins), guides neurites to their target layer.
Data show that Hedgehog (show SHH Proteins) signaling is required for commissure formation, glial bridge formation, and the restricted expression of the guidance molecules slit1a, slit2 (show SLIT2 Proteins), slit3 (show SLIT3 Proteins) and sema3d (show SEMA3D Proteins).
Robo2 (show ROBO2 Proteins) acted initially to split the tract of the postoptic commissure into discrete fascicles upon entering a broad domain of Slit1a expression in the ventrocaudal diencephalon.
homolog of Drosophila slit\; may play a role in protein-protein interactions during midline formation in the central nervous system\; specifically expressed in fetal and adult forebrain neurons
slit homolog 1 protein
, multiple EGF-like domains protein 4
, multiple epidermal growth factor-like domains protein 4
, multiple epidermal growth factor-like domains 4
, slit homolog 1 (Drosophila)
, slit homolog 1
, slit homolog 1 protein-like