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We have studied the relation of CD1d expression in various breast cancer cell lines to their viability and progression. We observed a novel phenomenon that CD1d expression level increases with the progressive stage of the cancer.
CD1D has a role in disease progression and survival of chronic lymphocytic leukemia and may interact with CD161
CD1d-expressing cells isolated from peripheral blood of allogeneic hematopoietic stem cell transplantation patients showed the suppressive activity of T cell proliferation and higher expression of MyD88 (show MYD88 Proteins) and IDO (show IDO1 Proteins) compared with CD1d(-) cells.
These findings suggest that VP22 is required (but not sufficient) for the inhibition of CD1d-mediated antigen presentation in herpes simplex virus type 1 infection.
FasL (show FASL Proteins) expression in splenic CD5 (show CD5 Proteins)(+)CD1d(hi) B cells was decreased compared to the control group after TLR4 (show TLR4 Proteins) ligation.
The expression of CD1d showed a significantly negative correlation with CD86 (show CD86 Proteins) level in B cells from imiquimod (IMQ)-treated mice, B6.MRLlpr mice, and lupus erythematosus (SLE) patients.
CD1d-restricted peripheral T cell lymphoma in mice and humans
BCR-ABL-dependent ROCK, but not TK, is involved in CD1d downregulation. We propose that ROCK, which is most likely activated by the DH/PH domain of BCR-ABL, mediates iNKT-cell immune subversion in chronic myeloid leukaemia (CML) patients by downregulating CD1d expression on CML mDCs.
Importantly, among the analyzed molecules, only CD1d expression showed an association with the activation of double-negative T cells, as well as with worse ventricular function in patients with Chagas disease.
Data suggest that CD1d antigen (show KY Proteins)-restricted B lymphocytes (Bc) presentation of NGcGM3 drives effective invariant natural killer T cells (iNKT) activation.
Data indicate that bovine CD1d is able to bind glycosphingolipids (GSLs) with fatty acid chain lengths of C18 (show BBS9 Proteins), while GSLs with fatty acids of C24 do not bind.
The expression profile of CD1d mRNA in Rhesus macaque is in accordance with the tissue distribution and the functions of NKT (show SLC22A6 Proteins) cells in other species.
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail.
CD1D antigen, d polypeptide
, HMC class I antigen-like glycoprotein CD1D
, T-cell surface glycoprotein CD1d
, antigen-presenting glycoprotein CD1d
, differentiation antigen CD1-alpha-3
, thymocyte antigen CD1D