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Our findings provide clues regarding the role of FOXJ1 as a tumor inducer in bladder cancer and an enhancer in glycolysis. Targeting FOXJ1 could be a potential therapeutic strategy in bladder cancer.
Findings demonstrate that increased FOXJ1 contributes to the progression of CRC, which might be associated with the promotion effect of b-catenin nuclear translocation.
In ependymomas and choroid plexus tumours, reduced expression of FOXJ1 and its ciliogenesis programme are markers of poor outcome
Decreased FOXJ1 expression was correlated with clinic stage, lymph node metastasis, and distant metastasis, and lower FOXJ1 expression independently predicted shorter survival time in gastric carcinoma.
Both protein and mRNA levels of ciliogenesis-associated markers CP110, Foxj1, TAp73 (show TP73 Proteins) were significantly increased in patients with nasal polyps versus those seen in control subjects and were positively correlated with cilia length
By stimulating ciliogenesis with the transcription factor FOXJ1, it may be possible to maintain close to normal cilia length despite the stress of cigarette smoking.
Nanog (show NANOG Proteins)-mediated cell migration and invasion involved its regulation of E-cadherin (show CDH1 Proteins) and FOXJ1.
FOXJ1 is an important regulator of cilia gene expression during ciliated cell differentiation, with RFX3 (show RFX3 Proteins) as a transcriptional co-activator to FOXJ1.
FOXJ1 was overexpressed in HCCs (show HCCS Proteins) and associated with histological grade and poor prognosis.
Rer1p depletion reduced ciliary length and function by increasing gamma-secretase complex assembly and activity and, consequently, enhancing Notch (show NOTCH1 Proteins) signaling as well as reducing Foxj1a expression.
genome-wide expression profiles of undifferentiated E14.5 vs. abundantly ciliated E18.5 micro-dissected airway epithelia as well as Foxj1(+) vs. Foxj1-deficient foetal (E16.5) lungs of the mouse were compared using microarray hybridisation.
p73 (show ARHGAP24 Proteins) drives multiciliogenesis, both through transcriptional activation of a master ciliogenesis transcription factor FoxJ1 and through regulation of multiple genes central to ciliogenesis.
MYB (show MYB Proteins) has an early, crucial and conserved role in multiciliogenesis, and it promotes a novel S-like phase in which centriole amplification occurs uncoupled from DNA synthesis, and then drives later steps of multiciliogenesis through induction of Foxj1.
noto and foxj1 have roles in node formation, nodal ciliogenesis and cilia positioning
we found that Ank3 expression is controlled by Foxj1, a transcriptional regulator of multicilia formation.
Dlx2 and FoxJ1 physically interact and synergistically regulate the Dlx2, FoxJ1, and amelogenin (show AMELX Proteins) promoters
Data show that floor plate identity and ciliogenesis are unaffected in mouse embryos lacking Foxj1 and we provide evidence that additional transcription factors expressed in the floor plate share overlapping functions with Foxj1.
foxj1 functions in late-stage ciliogenesis to regulate programs promoting basal body docking and axoneme formation in cells previously committed to the ciliated cell phenotype.
role in the regulation of T cell activation and autoreactivity; Foxj1 likely modulates inflammatory reactions and prevents autoimmunity by antagonizing proinflammatory transcriptional activities
This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.
forkhead transcription factor J1
, forkhead box J1
, forkhead box protein J1-like
, forkhead box J protein
, fork head homologue 4
, forkhead box protein J1
, forkhead transcription factor HFH-4
, forkhead-like 13
, forkhead-related protein FKHL13
, hepatocyte nuclear factor 3 forkhead homolog 4
, HNF-3/forkhead homolog 4