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anti-Human NFYB Antibodies:
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Cow (Bovine) Polyclonal NFYB Primary Antibody for WB - ABIN2780750
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
Show all 2 Pubmed References
The nuclear transcription factor Y subunit beta (NFYB)-E2F transcription factor 1 (E2F1) pathway displays a crucial role in the chemoresistance ofoxaliplatin-resistant colorectal cancer (OR-CRC) by inducing the expression and activation of checkpoint kinase 1 (CHK1), suggesting a possible therapeutic target for oxaliplatin resistance in CRC.
Data indicate that specific cancer-driving nodes are generally under NF-YA/B control.
Presence of NF-Y transcription factor plays a pivotal role in transcriptional regulation of ID genes in development.
NF-YB transcription factor was identified as a novel direct E2F1 target.
The NF-Y complex is asymmetric, with NF-YB binding approximately 15 bp downstream from the CCAAT motif.
The crystal structure of NF-Y bound to a 25 bp CCAAT oligonucleotide shows that the histone-fold domains dimer binds to the DNA sugar-phosphate backbone, mimicking the nucleosome H2A/H2B-DNA assembly; NF-YA both binds to NF-YB/NF-YC and inserts an alpha helix deeply into the DNA minor groove, providing sequence-specific contacts to the CCAAT box.
Transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 in acute myeloid leukemia.
NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L
MicroRNA-485-3p regulates drug responsiveness by decreasing nuclear factor-YB expression, which in turn negatively regulates DNA topoisomerase IIalpha.
The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y.
p300 binds to multiple NF-Y trimers to regulate cyclin B2 promoter function
CBF/NF-Y proteins regulate the transcription of COL11A1 by directly binding to the ATTGG sequence in the proximal promoter region
Histone deacetylase inhibitors can induce Gadd45 through its promoter without the need for functional p53, and both Oct-1 and NF-Y concertedly participate in trichostatin A-induced activation of the gadd45 promoter.
p53 negatively regulates Chk2 gene transcription through modulation of NF-Y function and that this regulation may be important for reentry of cells into the cell cycle after DNA damage is repaired.
Co-operative functional interactions between Sp1 & NF-Y are required to direct the activity of the ATP1A3 promoter predominantly in neuronal cells.
trichostatin A activates the transcription of TSP1 gene through the binding of transcription factor CBF to CCAAT box and the enhanced histone acetylation.
CBF-A is a novel transacting factor required for cytoplasmic mRNA transport and localization
results exclude NFYB as candidate gene for congenital splay leg but provide a basis for selection of further candidates for the disease from SSC5
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence\; protein sequence alignments and experiments with mutants.
nuclear transcription factor Y, beta
, nuclear transcription factor Y subunit beta
, CAAT box DNA-binding protein subunit B
, CCAAT-binding transcription factor subunit A
, Transcription factor NF-Y, B subunit
, nuclear transcription factor Y subunit B
, nuclear Y/CCAAT-box binding factor B subunit NF-YB
, CAAT-box DNA binding protein subunit B (NF-YB)
, CAAT-box DNA-binding protein subunit B
, nuclear transcription factor Y beta
, CCAAT binding transcription factor of CBF-B/NFY-B
, nuclear transcription factor - Y beta