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KPNB1 (show KPNB1 Proteins) and Ran protein jointly mediated the nuclear import of NDV M protein (show MYOM2 Proteins), showing that KPNB1 (show KPNB1 Proteins) protein interacted with NDV M protein (show MYOM2 Proteins) to form binary complex and then entered into the nucleus with the assistance of Ran protein.
Ran GTPase promotes cancer progression via Met recepto-rmediated downstream signaling
Data show that the distribution of components of the ras-related nuclear protein (Ran) pathway that influence microtubule behaviors is determined by their interactions with microtubules, resulting in microtubule nucleators being localized by the microtubules whose formation they stimulate.
The RAS-related nuclear protein ((P) ran), breast cancer metastasis suppressor 1 (show BRMS1 Proteins) ((P) brms1 (show BRMS1 Proteins)) and minichromosome maintenance complex component 5 (show MCM5 Proteins) ((P) mcm5 (show MCM5 Proteins)) promoters have the specificity and strength needed for cancer-specific expression-targeted gene therapy.
Authors found that decreasing Ran-GTP (show AK3 Proteins) levels or tethering active Ran to the equatorial membrane affects anillin's localization and causes cytokinesis phenotypes.
lysine-acetylation regulates nearly all aspects of Ran-function such as RCC1 (show RCC1 Proteins) catalyzed nucleotide exchange, intrinsic nucleotide hydrolysis, its interaction with NTF2 (show NUTF2 Proteins) and the formation of import- and export-complexes.
These results showed that BLM enters the nucleus via the importin beta1, RanGDP and NTF2 dependent pathway, demonstrating for the first time the nuclear trafficking mechanism of a DNA helicase.
RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2
we demonstrated that DICER (show DICER1 Proteins) (rs3742330) and RAN (rs14035) were associated with the survival of HCC (show FAM126A Proteins) patients
RAN translation from antisense CCG repeats generates novel proteins that accumulate in ubiquitinated inclusions in Fragile X-associated tremor/ataxia syndrome patients.
Data suggest Ran activation by RanBP1 (show RANBP1 Proteins) in macrophages promotes Legionella phagosome formation and phagocytosis; LegG1 functions as bacterial Ran activator, localizes to phagosomes, and promotes microtubule stabilization, phagocytosis, and replication.
Augmented expression of Ran in progranulin (show GRN Proteins)-deficient neurons restores nuclear TDP-43 (show TARDBP Proteins) levels and improves their survival.
Reduction in Ran levels causes cytoplasmic decrease and nuclear accumulation of importin alpha leading to cellular senescence in normal cells.
a novel connection between the hyper-activation of the small GTPase Ran and the matricellular protein SMOC-2 (show SMOC2 Proteins) that has important consequences for oncogenic transformation.
A critical function of RanBP2 is to capture recycling RanGTP-importin-beta (show KPNB1 Proteins) complexes at cytoplasmic fibrils to allow for adequate classical nuclear localization signal-mediated cargo import.
Downregulation of the Ran GTPase effector RanBP1 (show RANBP1 Proteins) is required for nuclear reorganisation.
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.
intracellular Ran protein levels control the nuclear retention for selective transcription factors such as c-Jun (show JUN Proteins) and c-Fos of AP-1 (show JUN Proteins), which is known to be critical in T cell activation and proliferation and lymphokine (show IL2 Proteins) secretion.
expression of Ran/M1 (show TLR4 Proteins) and Ran/M2 increased in pachytene spermatocytes with progressive transcript accumulation until they reached the round spermatid stage, in the seminiferous epithelium of adults
RanGDP is regulated by phosphorylation and regulated by NTF2 (show NUTF2 Proteins)
the Canoe Ras-association (RA) domains directly bind RanGTP
Knockdown of the small G protein Ran, which is essential for nuclear transport, leads to an arrest of EcR in the cytoplasm, but does not prevent efficient nuclear import of the most important heterodimerization partner of EcR, ultraspiracle (Usp).
results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI (show SMARCA5 Proteins) and that this is essential for proper chromosome segregation
gtpase ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos
anillin (show ANLN Proteins) and Peanut are involved in pseudocleavage furrow ingression in syncytial embryos, a process that is regulated by Ran
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
GTP-binding nuclear protein Ran
, GTPase Ran
, androgen receptor-associated protein 24
, guanosine triphosphatase Ran
, member RAS oncogene family
, ras-like protein TC4
, ras-related nuclear protein
, RAN, member RAS oncogene family
, RAN, member RAS oncogene family pseudogene 1
, Ran GTPase