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Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit (show POLG Proteins)
Geranylgeranyltransferase inhibitor-2147 (GGTI (show PGGT1B Proteins)-2147), an inhibitor of protein prenylation, elicited significant inhibition of glucose-stimulated insulin (show INS Proteins) secretion from INS (show INS Proteins) 832/13 islet cells.
FTase, via its tubulin (show TUBB Proteins)-association, is a critical upstream regulator of HDAC6 (show HDAC6 Proteins) activity
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13.
, farnesyl-protein transferase alpha-subunit
, protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
, protein prenyltransferase alpha subunit repeat containing 2
, ras proteins prenyltransferase subunit alpha
, type I protein geranyl-geranyltransferase alpha subunit
, CAAX farnesyltransferase subunit alpha
, type I protein geranyl-geranyltransferase subunit alpha
, Farnesyltransferase, subunit alpha