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RLIM Products

(Ring Finger Protein, LIM Domain Interacting (RLIM))

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The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009].

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Featured RLIM Categories

RLIM Antibodies

High quality antibodies with extensive validation data.

RLIM Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended RLIM Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IP
Validations
  • (3)
  • (7)
Cat. No. ABIN565536
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (5)
  • (1)
Cat. No. ABIN1881751
Quantity 400 μL
Datasheet Datasheet

Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN6735780
Quantity 100 μL
Datasheet Datasheet

Recommended RLIM ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6232234
Quantity 96 tests
Datasheet Datasheet

Recommended RLIM Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1318206
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1318208
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN2731016
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our RLIM products

Gao, Wang, Cai, Zhu, Yu: "E3 Ubiquitin Ligase RLIM Negatively Regulates c-Myc Transcriptional Activity and Restrains Cell Proliferation." in: PLoS ONE, Vol. 11, Issue 9, pp. e0164086, (2016) (PubMed).

Zhou, Drabsch, Dekker, de Vinuesa, Li, Hawinkels, Sheppard, Goumans, Luwor, de Vries, Mesker, Tollenaar, Devilee, Lu, Zhu, Zhang, Dijke: "Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-? signalling." in: Nature communications, Vol. 5, pp. 3388, (2014) (PubMed).

Fukuda, Tomikawa, Miura, Hata, Nakabayashi, Eggan, Akutsu, Umezawa: "The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice." in: Nature communications, Vol. 5, pp. 5464, (2014) (PubMed).

Jonkers, Barakat, Achame, Monkhorst, Kenter, Rentmeester, Grosveld, Grootegoed, Gribnau: "RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation." in: Cell, Vol. 139, Issue 5, pp. 999-1011, (2009) (PubMed).

Her, Chung: "Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1." in: The Journal of biological chemistry, Vol. 284, Issue 13, pp. 8557-66, (2009) (PubMed).

Johnsen, Güngör, Prenzel, Riethdorf, Riethdorf, Taniguchi-Ishigaki, Rau, Tursun, Furlow, Sauter, Scheffner, Pantel, Gannon, Bach: "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer." in: Cancer research, Vol. 69, Issue 1, pp. 128-36, (2009) (PubMed).

Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, (2007) (PubMed).

Xu, Meng, Cai, Liang, Nagarajan, Brandt: "Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins." in: Genes & development, Vol. 21, Issue 8, pp. 942-55, (2007) (PubMed).

Hiratani, Yamamoto, Mochizuki, Ohmori, Taira: "Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions." in: Development (Cambridge, England), Vol. 130, Issue 17, pp. 4161-75, (2003) (PubMed).

Ostendorff, Peirano, Peters, Schlüter, Bossenz, Scheffner, Bach: "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors." in: Nature, Vol. 416, Issue 6876, pp. 99-103, (2002) (PubMed).

Synonyms and alternative names related to RLIM

ring finger protein, LIM domain interacting (RLIM), ring finger protein, LIM domain interacting (Rlim), XRnf12C protein (xrnf12c), ring finger protein, LIM domain interacting (rlim), AL022832, AW743871, Ha1r, NY-REN-43, R-LIM, RNF12, Rnf12

Protein level used designations for RLIM

  • E3 ubiquitin-protein ligase RLIM
  • E3 ubiquitin-protein ligase RNF12
  • LIM domain-interacting RING finger protein
  • R-LIM
  • RING finger LIM domain-binding protein
  • renal carcinoma antigen NY-REN-43
  • ring finger protein 12
  • ring zinc finger LIM domain binding protein
  • ring zinc finger protein NY-REN-43antigen
  • Hoxa1 regulated
  • LIM domain interacting RING finger protein
  • rnf12
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