Ring Finger Protein 11-Like (RNF11L) (C-Term) Peptide
RNF11L
Reactivity: Human, Rat
Host: Synthetic
BP, WB
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- Target
- RNF11L (Ring Finger Protein 11-Like (RNF11L))
- Protein Region
- C-Term
- Origin
- Human, Rat
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- GLIQHLPKGG YDPGRDGSEK KIRECVICMM DFVYGDPIRF LPCMHIYHLD
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Rnf11l Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RNF11L (Ring Finger Protein 11-Like (RNF11L))
- Synonyms
- Rnf11 Peptide, ring finger protein 11-like 2 Peptide, Rnf11l2 Peptide
- Background
-
Rnf11l is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Rnf11l promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Rnf11l recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Alias Symbols: Rnf11
Protein Size: 280 - Molecular Weight
- 30 kDa
- Gene ID
- 316552
- NCBI Accession
- XM_237327, XP_237327
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