|Antigen||Actin Related Protein 2/3 Complex, Subunit 3, 21kDa (ARPC3) Antibodies|
|Epitope||AA 10-118 Alternatives|
|Reactivity||Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This ARPC3 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Western Blotting (WB)
|2 references available|
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Product Details anti-ARPC3 AntibodyTarget Details ARPC3 Application Details Handling References for anti-ARPC3 antibody (ABIN968781) Images
|Cross-Reactivity||Mouse (Murine), Rat (Rattus), Chicken, Dog (Canine)|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human p21-Arc aa. 10-118|
Target Details ARPC3Product Details anti-ARPC3 Antibody Application Details Handling References for anti-ARPC3 antibody (ABIN968781) Images back to top
|Alternative Name||p21-Arc (ARPC3 Antibody Abstract)|
|Background||Cellular morphology, adhesion, and motility occur through the reorganization of the actin cytoskeleton. This reorganization of actin filaments occurs through the interactions between actin and actin binding proteins. Actin-binding proteins regulate the polymerization and depolymerization of actin, connect actin-based structures to membranes and to other cytoskeletal elements, power the movement of actin filaments, and cross-link actin filaments into bundles. Actin related proteins (Arp) 2/3 complex is an actin polymerization inducing complex that includes Arp2, Arp3, p41-Arc, p34-Arc, p21-Arc, p20 Arc, and p16-Arc. The Arp2 and Arp3 subunits may nucleate actin polymerization, while the p41-Arc subunit is a WD repeat-containing protein that may regulate both the activity and localization of the Arp2/3 complex. Arp3, p34-Arc, and p21-Arc are localized to the lamellipodia of stationary and locomoting fibroblasts. Both WASP and Abp1p are acidic sequence-containing proteins that activate the Arp2/3 complex. However, WASP binds actin monomers, while the endocytosis-related Abp1p protein binds actin filaments. Thus, Arp2/3 complex may regulate actin polymerization in specific cell locations through interaction with actin binding Arp2/3 activators.|
|Molecular Weight||21 kDa|
|Pathways||RTK Signaling, Regulation of Actin Filament Polymerization|
Application DetailsProduct Details anti-ARPC3 Antibody Target Details ARPC3 Handling References for anti-ARPC3 antibody (ABIN968781) Images back to top
Related Products: ABIN968535, ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-ARPC3 Antibody Target Details ARPC3 Application Details References for anti-ARPC3 antibody (ABIN968781) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20° C.|
References for anti-ARPC3 antibody (ABIN968781)Product Details anti-ARPC3 Antibody Target Details ARPC3 Application Details Handling Images back to top
|Product cited in:||
Zhao, Yang, Qian, Zhu: "Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub." in: Biochemical and biophysical research communications, Vol. 280, Issue 2, pp. 513-7, 2001
Welch, DePace, Verma, Iwamatsu, Mitchison: "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly." in: The Journal of cell biology, Vol. 138, Issue 2, pp. 375-84, 1997
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