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Senataxin Products

(Senataxin (SETX))
This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4). [provided by RefSeq, Jul 2008].

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Featured Senataxin Categories

Senataxin Antibodies

High quality antibodies with extensive validation data.

Senataxin ELISA Kits

Reliable ELISA kits for a wide range of species.

Recommended Senataxin Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (5)
Cat. No. ABIN565001
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7164533
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC
Validations
  • (1)
Cat. No. ABIN1385872
Quantity 100 μL
Datasheet Datasheet

Recommended Senataxin ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1149656
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1149655
Quantity 96 tests
Datasheet Datasheet

Recommended Senataxin Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319693
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293T Cells
Validations
  • (1)
Cat. No. ABIN2731631
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our Senataxin products

Makharashvili, Arora, Yin, Fu, Wen, Lee, Kao, Leung, Miller, Paull: "Sae2/CtIP prevents R-loop accumulation in eukaryotic cells." in: eLife, Vol. 7, (2019) (PubMed).

Cristini, Ricci, Britton, Salimbeni, Huang, Marinello, Calsou, Pommier, Favre, Capranico, Gromak, Sordet: "Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks." in: Cell reports, Vol. 28, Issue 12, pp. 3167-3181.e6, (2019) (PubMed).

Cohen, Puget, Lin, Clouaire, Aguirrebengoa, Rocher, Pasero, Canitrot, Legube: "Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations." in: Nature communications, Vol. 9, Issue 1, pp. 533, (2018) (PubMed).

Andrews, McCartney, Errington, DAndrea, Macara: "A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links." in: Nature communications, Vol. 9, Issue 1, pp. 2592, (2018) (PubMed).

Choudhury, Vs, Mushtaq, Kumar: "Altered translational repression of an RNA-binding protein, Elav by AOA2-causative Senataxin mutation." in: Synapse (New York, N.Y.), Vol. 71, Issue 5, (2017) (PubMed).

Nguyen, Yadav, Giri, Saez, Graubert, Zou: "Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1." in: Molecular cell, Vol. 65, Issue 5, pp. 832-847.e4, (2017) (PubMed).

Zhao, Gish, Braunschweig, Li, Ni, Schmitges, Zhong, Liu, Li, Moffat, Vedadi, Min, Pawson, Blencowe, Greenblatt: "SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination." in: Nature, Vol. 529, Issue 7584, pp. 48-53, (2016) (PubMed).

Richard, Feng, Manley: "A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage." in: Genes & development, Vol. 27, Issue 20, pp. 2227-32, (2013) (PubMed).

Synonyms and alternative names related to Senataxin

senataxin (SETX), senataxin (setx), senataxin (Setx), A130090N03, A930037J23Rik, ALS4, Als4, AOA2, AW060766, bA479K20.2, mKIAA0625, RGD1565575, SCAR1, Sen1, SETX, wu:fj92h09

Protein level used designations for Senataxin

  • senataxin
  • amyotrophic lateral sclerosis 4
  • probable helicase senataxin-like
  • SEN1 homolog
  • amyotrophic lateral sclerosis 4 protein
  • probable helicase senataxin
  • amyotrophic lateral sclerosis 4 homolog
  • amyotrophic lateral sclerosis 4 protein homolog
  • DEAxQ-box helicase
  • tRNA splicing endonuclease regulator 1
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