SMG1 Products
(pi-3-Kinase-Related Kinase SMG-1 (SMG1))
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This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013].
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SMG1 Antibodies
High quality antibodies with extensive validation data.
SMG1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended SMG1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC (p)
Validations
- (2)
- (4)
Cat. No.
ABIN524936
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC (p)
Validations
- (4)
Cat. No.
ABIN524937
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IF
Validations
- (3)
Cat. No.
ABIN564996
Quantity
100 μg
Datasheet
Datasheet
Recommended SMG1 ELISA Kits
Recommended SMG1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320674
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our SMG1 products
: "Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 5, pp. 1257-67, (2012) (PubMed).: "The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8." in: Genes & development, Vol. 25, Issue 2, pp. 153-64, (2011) (PubMed).
: "Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure." in: The Journal of biological chemistry, Vol. 286, Issue 8, pp. 6641-9, (2011) (PubMed).
: "Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly." in: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 20109-16, (2010) (PubMed).
: "Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 27, pp. 12186-91, (2010) (PubMed).
: "Processing bodies are not required for mammalian nonsense-mediated mRNA decay." in: RNA (New York, N.Y.), Vol. 15, Issue 7, pp. 1265-73, (2009) (PubMed).
: "Circadian oscillation of nucleotide excision repair in mammalian brain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 8, pp. 2864-7, (2009) (PubMed).
: "The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells." in: Molecular cell, Vol. 14, Issue 5, pp. 585-98, (2004) (PubMed).
: "The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways." in: DNA repair, Vol. 3, Issue 8-9, pp. 919-25, (2004) (PubMed).
: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).
Synonyms and alternative names related to SMG1
SMG1, nonsense mediated mRNA decay associated PI3K related kinase (SMG1), SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) (Smg1), SMG1 phosphatidylinositol 3-kinase-related kinase (smg1), Serine/threonine-protein kinase smg-1 (smg-1), 61E3.4, 2610207I05Rik, 5430435M13Rik, ATX, C130002K18Rik, LIP, mKIAA0421, zgc:152973Protein level used designations for SMG1
- PI-3-kinase-related kinase SMG-1
- lambda-interacting protein
- lambda/iota protein kinase C-interacting protein
- serine/threonine-protein kinase SMG1
- smg-1 homolog, phosphatidylinositol 3-kinase-related kinase
- SMG-1
- phosphatidylinositol 3-kinase-related protein kinase
- SMG1 homolog, phosphatidylinositol 3-kinase-related kinase
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