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silencing ZFP36L2 inhibited cancer cell aggressiveness in pancreatic ductal adenocarcinoma cell lines, and overexpression of ZFP36L2 was confirmed in pancreatic ductal adenocarcinoma clinical specimens
Study of the role of the C-terminal residues in the structure of unbound TIS11d, the E220A mutant and the truncation mutant lacking the last two residues (D219/E220) using molecular dynamics, NMR spectroscopy, and biochemical methods
The roles of TTP (show ADAMTS13 Proteins) and BRF (show BRF1 Proteins) proteins in regulated mRNA decay.
Data suggest that the dysregulation of TIS11D function is associated with the pathogenesis of certain types of leukemia.
ZFP36L2 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.
Multiple nanosecond timescale molecular dynamics trajectories of TIS11d wild-type and E157R/E195K mutant with different RNA sequences were performed to investigate the molecular basis for RNA binding specificities of this TZF domain.
polymorphisms sequenced in genomic DNA encoding the TTP (show ADAMTS13 Proteins) protein (ZFP36 (show ZFP36 Proteins)) and those of its two known mammalian relatives, ZFP36L1 (show ZFP36L1 Proteins) and ZFP36L2, from 72 to 92 anonymous human subjects from various geographical and ethnic backgrounds
Sequence specificity in RNA recognition is achieved by a network of intermolecular hydrogen bonds, mostly between TIS11d main-chain functional groups and the Watson-Crick edges of the bases
These data suggest TIS11D as a candidate p53 (show TP53 Proteins) target gene that may be part of the network of genes responsible for p53 (show TP53 Proteins)-dependent apoptosis.
The Zfp36l2 therefore act as posttranscriptional safeguards against chromosomal instability and replication stress by integrating pre-TCR and IL-7 (show IL7 Proteins) signaling with DNA damage and cell cycle control.
Study tested for the first time a role of ZFP36L2 in the decay of LHR (show LHCGR Proteins) mRNA, when transcription was inhibited; results of our cell-based assay support the conclusion that LHR (show LHCGR Proteins) mRNA expression is controlled post-transcriptionally by ZFP36L2.
ZFP36L1 (show ZFP36L1 Proteins) and ZFP36L2 suppress an evolutionarily conserved posttranscriptional regulon consisting of messenger RNAs whose protein products cooperatively promote transition into the S phase of the cell cycle.
In mature peripheral neurons, ZFP36L2 mediates post-transcriptional mechanisms by promoting axonal integrity.
lack of the physiological down regulation of luteinizing hormone receptor (show LHCGR Proteins) mRNA levels by ZFP36L2 in the ovaries is associated with anovulation and oocyte meiotic arrest
ZFP36L2 therefore functions as part of a molecular switch promoting BFU-E self-renewal and a subsequent increase in the total numbers of colony-forming unit-erythroid (CFU-E) progenitors and erythroid cells that are generated
Data revealed that ZFP36L1 (show ZFP36L1 Proteins) and ZFP36L2 bound to the 3' untranslated region (UTR) of MAPK phosphatase-1 (MKP-1 (show DUSP1 Proteins)) mRNA and downregulated Mkp-1 (show DUSP1 Proteins) 3'UTR-mediated luciferase activity.
ZFP36L2 has a critical role in lymphocyte development and may function as a tumor suppressor.
model of disruption of the earliest stages of embryogenesis, implicating Zfp36l2, a probable mRNA-binding and destabilizing protein, in the physiological control of female fertility at the level of early embryonic development
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors.
EGF-response factor 2
, ZFP36-like 2
, butyrate response factor 2
, zinc finger protein 36, C3H type-like 1
, zinc finger protein 36, C3H type-like 2
, zinc finger protein 36, C3H1 type-like 2
, zinc finger protein, C3H type, 36-like 2
, zinc finger protein 36, C3H type-like 2-like
, CCCH zinc finger protein 3-B
, CCCH zinc finger protein C3H-3
, zinc finger protein 36, C3H1 type-like 2-B
, LOW QUALITY PROTEIN: zinc finger protein 36, C3H1 type-like 2
, mRNA decay activator protein ZFP36L2