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Browse our anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antibodies

Full name:: anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Antibodies (APBA1)

On www.antibodies-online.com are 79 Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antibodies from 21 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 89 Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 products are currently listed.

Synonyms:: 6430513E09Rik, APBA1, D9S411E, Lin-10, LIN10, Mint, MINT1, Urop11, X11, X11A, X11ALPHA

list all antibodies	Gene Name	GeneID	UniProt
	APBA1	319924	B2RUJ5
	APBA1	83589	O35430
	APBA1	320	Q02410
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Most Popular Reactivities for anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antibodies

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Relevant Pathways for anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Antibodies

Top referenced anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Antibodies

Human Polyclonal APBA1 Primary Antibody for ELISA, WB - ABIN451592 : Jacobs, Williams, Francis: Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease. in Neuroscience 2006 (PubMed)
Human Polyclonal APBA1 Primary Antibody for WB - ABIN541353 : Verlaeten, Casery, Cavagna, Naville, Giraudon, Belin, Begeot, Bernard: Identification of Urop11, a novel leptin-modulated gene that is upregulated in the hypothalamus of mice with virus-induced obesity. in Journal of molecular endocrinology 2007 (PubMed)
Rat (Rattus) Polyclonal APBA1 Primary Antibody for ICC, IHC - ABIN1742315 : Boyken, Grønborg, Riedel, Urlaub, Jahn, Chua: Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. in Neuron 2013 (PubMed)

More Antibodies against Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Interaction Partners

Mouse (Murine) Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) interaction partners

Results indicate that both X11 and X11L exert largely in brain neurons, but X11 may also function in peripheral tissues.
Due to the multiple interacting partners of X11alpha, dysfunction or alteration in X11alpha will have a significant cellular effect.
Mint1 826 bridges APP to the small GTPase
Expression of Apba1 in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).
Our data support a function for both GSK3 and CDK5 in amyloid precursor protein processing, further implicating these two kinases in the pathogenesis of Alzheimer's disease.
Mints are important regulators of presynaptic neurotransmitter release that are essential for mouse survival.
Can be considered a key molecule in the hypothalamic integration pathway, important as a target of leptin action.
Reports have demonstrated that KIF17-Mint1 association was disrupted and transported cargo was released from its microtubule-based transport when Ser 1029 of KIF17 was phosphorylated.
X11s associate primarily with APP molecules that are outside of DRM, that the dissociation of APP-X11/X11L complexes leads to entry of APP into DRM, and that cleavage of uncomplexed APP by BACE within DRM
These results suggest that the three Mint/X11 proteins regulate Abeta production by a novel mechanism that may have implications for therapeutic approaches to altering APP cleavage in Alzheimer's disease.

Human Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) interaction partners

Mint1 causes amyloid precursor protein accumulation in the trans-Golgi network.
Mints are necessary for activity-induced APP and PS1 trafficking and provide insight into the cellular fate of APP in endocytic pathways essential for Abeta production.
Mint1 826 bridges APP to the small GTPase
an autoinhibitory mechanism in Mint1 is important for regulating APP processing and may provide novel therapies for Alzheimer's disease
Transcriptional co-activators Taz and Yap mediate signaling via the amyloid beta protein precursor paralogues APLP1 and APLP2 through interactions with Mint1 and Mint3.
Study identified the conserved binding site for the peptide on the CASK calmodulin kinase domain. A related EPIWVMRQ peptide from Mint1 was also discovered to be sufficient for binding.
Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis.
Methylation of MINT1 was significantly more prevalent in UC-CRC cases compared with controls.
ApoEr2 regulates cell movement, and both X11alpha and Reelin enhance this effect.
A novel consensus sequence for interaction with the PDZ-1 and PDZ-2 domains of amyloid precursor protein (APP)-interacting proteins Mint1, Mint2, and Mint3 is reported, with multiple novel interactors for these proteins.
Munc18a acts through direct and indirect interactions with X11 proteins and powerfully regulates APP metabolism and Abeta secretion.
Coexpression of X11alpha with amyloid protein precursor retarded its maturation, prolonged its half-life, and inhibited amyloid protein precursor, Abeta40, and Abeta42 secretion.
human X11alpha inhibits Abeta production and deposition in vivo in the brain in transgenic mice harboring a familial Alzheimer's disease mutant APP that produces increased levels of Abeta.
Involvement of X11L in the phosphorylation of APP family proteins in cellular stress and suggest that X11L protein may be .
X11alpha and X11beta have roles in beta-amyloid precursor protein processing
Mediates exocytosis and decreases beta-amyloid peptide formation in Alzheimer disease.
Data show that neuronal munc18-1-interacting protein 1 is an inclusion body component in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture.

Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.

Alternative names and synonyms associated with Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1)

amyloid beta precursor protein binding family A member 1 (APBA1) antibody
amyloid beta (A4) precursor protein-binding, family A, member 1b (apba1b) antibody
ketopantoate reductase (apbA1) antibody
2-dehydropantoate 2-reductase (apbA1) antibody
2-dehydropantoate 2-reductase (apba1) antibody
amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) (apba1) antibody
amyloid beta (A4) precursor protein-binding, family A, member 1 (apba1) antibody
amyloid beta (A4) precursor protein binding, family A, member 1 (Apba1) antibody
amyloid beta precursor protein binding family A member 1 (Apba1) antibody

6430513E09Rik antibody
APBA1 antibody
D9S411E antibody
Lin-10 antibody
LIN10 antibody
Mint antibody
MINT1 antibody
Urop11 antibody
X11 antibody
X11A antibody
X11ALPHA antibody

Protein level used designations for APBA1

amyloid beta (A4) precursor protein-binding, family A, member 1 , amyloid beta A4 precursor protein-binding, family A, member 1 , amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) , ketopantoate reductase , 2-dehydropantoate 2-reductase , Amyloid beta A4 precursor protein-binding family A member 1 , amyloid beta A4 precursor protein-binding family A member 1-like , UROP11-110 , adapter protein X11alpha , amyloid beta A4 precursor protein-binding family A member 1 , mint-1 , neuron-specific X11 protein , neuronal Munc18-1-interacting protein 1 , amyloid beta (A4) precursor protein-binding family A APBA1: amyloid beta (A4) precursor protein-binding family A member 1 (X11) , amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) , adaptor protein X11alpha , neuronal munc18-1-interacting protein 1 , phosphotyrosine-binding/-interacting domain (PTB)-bearing protein

GENE ID	SPECIES
472947	Pan troglodytes
565507	Danio rerio
699838	Macaca mulatta
4247161	Ralstonia eutropha H16
4606254	Azoarcus sp. BH72
9788884	Pantoea vagans C9-1
100380423	Salmo salar
100390315	Callithrix jacchus
100439123	Pongo abelii
100483732	Ailuropoda melanoleuca
100485825	Xenopus (Silurana) tropicalis
319924	Mus musculus
83589	Rattus norvegicus
320	Homo sapiens
427246	Gallus gallus
100686233	Canis lupus familiaris
100513711	Sus scrofa
515571	Bos taurus

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Show all anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antibodies with Pubmed References

Mouse (Murine) Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) interaction partners

Human Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) interaction partners

Antigen Summary

Alternative names and synonyms associated with Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1)

Protein level used designations for APBA1