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anti-Human SYT1 Antibodies:
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Rat (Rattus) Polyclonal SYT1 Primary Antibody for IHC, WB - ABIN152576
Hilfiker, Pieribone, Nordstedt, Greengard, Czernik: Regulation of synaptotagmin I phosphorylation by multiple protein kinases. in Journal of neurochemistry 1999
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Human Monoclonal SYT1 Primary Antibody for ELISA, WB - ABIN969429
Xu, Gammon, Zeisel, Lee, Wetmur, Teitelbaum, Bradshaw, Neugut, Santella, Chen: Choline metabolism and risk of breast cancer in a population-based study. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
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Chicken Polyclonal SYT1 Primary Antibody for WB - ABIN2476661
Geertsen, Ford, Castle: The subjective aspects of coronary care. in Nursing research 1976
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Human Polyclonal SYT1 Primary Antibody for ELISA, IHC - ABIN4357223
Martens, Kozlov, McMahon: How synaptotagmin promotes membrane fusion. in Science (New York, N.Y.) 2007
Rat (Rattus) Polyclonal SYT1 Primary Antibody for ICC, WB - ABIN1742201
Shinoda, Ahmed, Ramachandran, Bharat, Brockelt, Altas, Dean: BDNF enhances spontaneous and activity-dependent neurotransmitter release at excitatory terminals but not at inhibitory terminals in hippocampal neurons. in Frontiers in synaptic neuroscience 2014
Human Monoclonal SYT1 Primary Antibody for ELISA, WB - ABIN967126
Stelzl, Worm, Lalowski, Haenig, Brembeck, Goehler, Stroedicke, Zenkner, Schoenherr, Koeppen, Timm, Mintzlaff, Abraham, Bock, Kietzmann, Goedde, Toksöz, Droege, Krobitsch, Korn, Birchmeier, Lehrach et al.: A human protein-protein interaction network: a resource for annotating the proteome. ... in Cell 2005
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that reduction in the synaptotagmin 1 level and presenilin 1 (show PSEN1 Antibodies)-synaptotagmin 1 interactions in AD brain may present molecular underpinning of the pathogenic presenilin 1 (show PSEN1 Antibodies) conformation
findings show extended Synaptotagmi1 (E-Syt1 (show ESYT1 Antibodies)), along with related E-Syt3 (show ESYT3 Antibodies), negatively modulates viral release into the extracellular milieu, cell-to-cell viral spread and viral entry, processes that implicate membrane fusion events; , these E-Syt (show SS18 Antibodies) proteins impacted formation of virus-induced syncytia; findings hint at the modulation of the viral fusion machinery by the E-Syt (show SS18 Antibodies) family of proteins
Using electron microscopy combined with targeted mutations, the authors show that under physiologically relevant conditions, both the Syt1 ring assembly and its rapid disruption by Ca(2+) involve the well-established functional surfaces on the C2B domain that are important for synaptic transmission.
This study found that the CSF (show CSF2 Antibodies) levels of synaptotagmin-1 were consistently elevated in patients with dementia due to Alzheimer's disease.
SYT (show SS18 Antibodies)-SSX (show SSX2 Antibodies) fusion is associated with synovial sarcoma.
the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function as PtdIns(4,5)P2- and Ca(2 (show CA2 Antibodies)+)-regulated tethers to the Pplasma membrane.
Data indicate that small protein sequence changes in the Ca(2 (show CA2 Antibodies)+)-binding loops of the C2 domains may give rise to the difference in binding kinetics between Syt-1 and Syt-7 (show SYT7 Antibodies) isoforms.
These findings identify Syt1 as a novel Ca(2 (show CA2 Antibodies)+)-sensitive PS1 (show PSEN1 Antibodies) modulator that could regulate synaptic ABETA (show APP Antibodies), opening avenues for novel and selective synapse targeting therapeutic strategies.
One-Step reverse transcriptase real time PCR for the detection SYT (show SS18 Antibodies)-SSX (show SSX2 Antibodies) transcript is feasible as an aid in confirming the diagnosis of synovial sarcoma.
membrane tethering by E-Syt1 (show ESYT1 Antibodies) (ER to PM) and by synaptotagmin (secretory vesicles to PM) undergo a similar regulation by plasma membrane lipids and cytosolic Ca(2 (show CA2 Antibodies)+).
tethering of Syt1 to synaptic vesicles in vivo is a prerequisite for its role in facilitating fast synchronous synaptic vesicle release and suppressing asynchronous and spontaneous fusion
synaptic transmission can be regulated by Syt1 multimerization and that both C2 domains of Syt1 are uniquely required for modulating Ca(2 (show CA2 Antibodies)+)-independent spontaneous fusion and Ca(2 (show CA2 Antibodies)+)-dependent synchronous release.
effect of APP (show APP Antibodies) gene on synaptotagmin 1 mRNA level
The major function of Ca2+ binding to synaptotagmin's C2A domain is to neutralize the negative charge of the pocket, thereby unleashing the fusion-stimulating activity of synaptotagmin.
this study provided direct support for the hypothesis that plasma membrane penetration, specifically by the C(2)B domain of synaptotagmin, is the critical effector interaction for coupling Ca(2 (show CA2 Antibodies)+) binding with vesicle fusion
Results suggest that the tandem C2 domains of Syt 1 play independent roles in neurotransmission.
The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo
Synaptotagmins I and IV promote transmitter release independently of Ca(2 (show CA2 Antibodies)+) binding in the C(2)A domain
Data show that synaptotagmin I is required for a post-docking step during vesicle fusion but does not function to stabilize the docked vesicle state.
These results indicate that synaptotagmin is the major Ca(2 (show CA2 Antibodies)+) sensor for evoked release and functions to trigger synchronous fusion in response to Ca(2 (show CA2 Antibodies)+), while suppressing asynchronous release.
Authors propose that the strong reduction of Syt2 (show SYT2 Antibodies) and SV2B (show SV2B Antibodies) are key factors of the functional synaptic alteration and that the physiological downregulation of Syt1 plays a determinant role in muscle vulnerability in SMA (show SMN1 Antibodies).
The function of synaptotagmin-1 (syt-1):soluble NSF attachment protein (show NAPG Antibodies) receptor (SNARE (show VTI1B Antibodies)) interactions during neurotransmission remains unclear.
we identify Syt2 (show SYT2 Antibodies) as a functionally important Ca(2 (show CA2 Antibodies)+) sensor at fast-releasing inhibitory synapses, and show that Syt1 and Syt2 (show SYT2 Antibodies) can redundantly control transmitter release at specific brain synapses
results suggest that postsynaptic Syt1 and Syt7 (show SYT7 Antibodies) act as redundant Ca(2 (show CA2 Antibodies)+)-sensors for Ca(2 (show CA2 Antibodies)+)-dependent exocytosis of AMPA (show GRIA3 Antibodies) receptors during long-term potentiation, and thereby delineate a simple mechanism for the recruitment of AMPA (show GRIA3 Antibodies) receptors that mediates LTP (show SCP2 Antibodies)
demonstrates a developmental Syt1-Syt2 (show SYT2 Antibodies) isoform switch at an identified synapse, a mechanism that could fine-tune the speed, reliability, and plasticity of transmitter release at fast releasing CNS synapses.
the combined inactivation of all 3 E-Syt (show SS18 Antibodies) genes has no effect on mouse viability or fertility.
We conclude that synaptotagmin-1 phosphorylation is an essential step in PKC (show PKC Antibodies)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (show PKC Antibodies) substrates, Munc13-1 (show UNC13A Antibodies) and Munc18-1 (show STXBP1 Antibodies).
data show that hepatic Syt1 expression is influenced by diet and hormonal milieu
different structural states of syt (show SS18 Antibodies) underlie the control of distinct forms of synaptic transmission.
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001
, synaptoptagmin 1
, synaptotagmin I
, synaptotagmin p65
, DKFZP459P193 protein
, Synaptotagmin I
, synaptotagmin I VQ/C2B-beta
, synaptotagmin 1 L homeolog