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General |
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Antigen | CD247 Molecule (CD247) Antibodies |
Reactivity | Hamster Alternatives |
Host | Hamster Alternatives |
Clonality (Clone) | |
Conjugate | This CD247 antibody is un-conjugated Alternatives |
Application |
Flow Cytometry (FACS), ELISA, Western Blotting (WB)
Alternatives
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Supplier | Log in to see |
Product Details anti-CD247 AntibodyTarget Details CD247 Application Details Handling Images |
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Specificity | Mouse CD3z (zeta chain) also known as CD247 |
Purification | Purified |
Immunogen | KLH conjugated mouse zeta-chain (CD3) sequence 151-164 . Donor: Armenian hamster |
Clone | H146-968 |
Isotype | IgG |
Target Details CD247Product Details anti-CD247 Antibody Application Details Handling Images back to top |
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Antigen | |
Alternative Name | CD3z (CD247 Antibody Abstract) |
Background | Purified Anti-Mouse CD3z Monoclonal Antibody detects the zeta subunit of the T cell receptor (TCR). The TCR complex consists of a ligand specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma, delta, eta and zeta subunits. This complex regulates assembly and expression of the receptor and is thought to be responsible for transmembrane transduction of signals after binding to TCR Studies have suggested that the CD3z subunit (also know as CD247) plays an important role in two distinct cellular compartments. In the cytoplasm, it may function to regulate Ag receptor expression and in the plasma membrane it may be required for optimal signaling by the physiologic ligand Ag/MHC. The CD3z subunit is also associated with the CD16 IgG Fc receptor on NK cells. This clone (H146-968) has been reported to work in flow cytometry (in permeabilized cells), Western Blotting and ELISA. |
Pathways | TCR Signaling, CXCR4-mediated Signaling Events |
Application DetailsProduct Details anti-CD247 Antibody Target Details CD247 Handling Images back to top |
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Application Notes | This clone (H146-968) has been reported to work in flow cytometry (in permeabilized cells), Western Blotting and ELISA. |
Restrictions | For Research Use only |
HandlingProduct Details anti-CD247 Antibody Target Details CD247 Application Details Images back to top |
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Concentration | 1.0 mg/ml |
Storage | 4 °C |