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findings show that mAbp1 and FHL2 (show FHL2 Proteins) are novel binding partners that differentially regulate Rho GTPase (show RACGAP1 Proteins) signaling and MTLn3 breast cancer cell invasion
Data suggest that by binding to both clathrin and F-actin, mammalian actin-binding protein 1 (mAbp1; HIP-55 or SH3P7) is specifically recruited at a late stage of clathrin-coated pits (CCPs) formation, which subsequently recruits dynamin (show DNM1 Proteins) to CCPs.
The results presented here indicate that targeting IL-1alpha with subcutaneous MABp1 adminisration has a strong potential therapeutic value in treating psoriasis and may provide a novel future treatment of this often devastating disease.
Data indicate that fourteen phosphorylation sites along the primary structure of hematopoietic progenitor kinase 1 (HPK1 (show MAP4K1 Proteins))-interacting protein of 55 kDa (HIP-55) rotein were identified.
HIP-55 expression promoted proliferation, colony formation, migration, and invasion of lung cancer cells and was upregulated in lung cancer cell lines and tumor tissues of lung cancer patients
Data suggest that HIP-55 could play an important role in the growth and cellular proliferation and HIP-55 dysfunction could be involved in tumorigenesis.
mAbp1 is of fundamental importance for spreading and migration under shear stress conditions, which are critical prerequisites for efficient PMN (show TBCE Proteins) extravasation during inflammation.
substrate for caspase (show CASP3 Proteins) cleavage during apoptosis
SH3P7 is essential for endocytosis but not lamellipodia formation.
HIP-55 plays a functional role in TCR signaling
These findings identify a novel role for mAbp1 in growth factor-induced dorsal ruffle formation through its interaction with WIP (show WIPF1 Proteins).[Abp1]
HIP-55 is a key novel component of the immunological synapse that modulates T cell activation by connecting actin cytoskeleton and TCRs to gene activation and endocytic processes
mAbp1 is likely to constitute a downstream effector of FYN binding protein involved in F-actin dynamics
HIP-55 has roles in T-cell proliferation, cytokine production, and immune responses
deficiency of SH3P7/mAbp1 in mouse mutants is associated with tissue abnormalities and impaired vesicle transport and their constricted physical capabilities and disturbed neuromotoric behaviour.
Abp1 facilitates BCR-mediated Ag processing by simultaneously interacting with dynamin and the actin cytoskeleton.
the genetic absence of mAbp1 almost completely abrogated firm neutrophil adhesion under physiologic shear stress conditions in vitro as well as leukocyte adhesion and extravasation in inflamed cremaster muscle venules
actin-binding protein involved in actin cytoskeleton organization in dendrites
HPK1-interacting protein of 55 kDa
, SH3 domain-containing protein 7
, cervical SH3P7
, cervical mucin-associated protein
, drebrin-like protein
, src homology 3 domain-containing protein HIP-55
, actin-binding protein 1
, drebrin-like protein B
, drebrin-like protein-like