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Low HLA-DRA expression is associated with sepsis.
In this prospective study we evaluated dynamic changes in monocyte HLA-DR expression during sepsis in relation to changes in HLA-DRA gene expression and Class II transactivator (CIITA (show CIITA Proteins)), measured by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR).
Case-control study in Han Chinese from the southwest of the country suggests that risk of ALS (show IGFALS Proteins) is increased by the AA genotype at rs9268856 in the HLA-DRA/HLA-DRB5 (show HLA-DRB5 Proteins) gene, but not by the SNPs rs9268877 in HLA-DRA/HLA-DRB5 (show HLA-DRB5 Proteins), rs1980493 in BTNL2 (show BTNL2 Proteins) or rs302668 in RAB38 (show RAB38 Proteins)/CTSC (show CTSC Proteins)
Kaposi's sarcoma-associated herpesvirus RTA not only downregulated HLA-DRalpha at the protein level through direct binding and degradation through the proteasome pathway but also indirectly downregulated the protein level of HLA-DRalpha by enhancing the expression of MARCH8, a member of the membrane-associated RING-CH (MARCH) proteins.
The frequency of CD14 (show NDUFA2 Proteins)(+)HLA-DR-/low MDSCs could be considered as a poor prognostic predictor in small-cell lung cancer (SCLC) and the elimination of MDSCs during medical interventions may improve the prognosis of SCLC patients.
This meta-analysis showed that the HLA-DRA rs3129882 A/G polymorphism was not a risk factor for Parkinson's disease in Chinese.
CD14 (show NDUFA2 Proteins)+HLA-DR(-/low) cells were significantly increased in gastric cancer tissue and were shown to have a critical role in CD4 (show CD4 Proteins)+T-cell immunosuppression.
No significant association was found for HLA-DRA/PARK18 (show EIF4G1 Proteins) rs3129882 polymorphism and Parkinson's disease risk (meta-analysis).
Increased CD14 (show NDUFA2 Proteins)+ monocytes with loss of HLA-DR expression were seen in patients with higher stage disease, more aggressive pathology, and in relapse or refractoriness to treatment.
HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping
ALOX5AP (show ALOX5AP Proteins), CPNE3 (show CPNE3 Proteins), IL1R2 (show IL1R2 Proteins), IL6 (show IL6 Proteins), TLR2, TLR4 (show TLR4 Proteins), and THY1 (show THY1 Proteins) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
Four unique SSCP patterns were detected among 384 cattle from New Zealand and sequence analysis revealed that these SSCP patterns represent 4 DRA alleles; and 3 single nucleotide polymorphisms were detected in exon 2
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
major histocompatibility complex, class II, DR alpha
, HLA class II histocompatibility antigen, DR alpha chain
, MHC cell surface glycoprotein
, MHC class II antigen DRA
, histocompatibility antigen HLA-DR alpha
, MHC class II DRA
, MHC class II antigen