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We developed an human cardiac alpha-myosin -induced myocarditis model in human HLA-DR4 transgenic mice that lack all mouse MHCII genes.
Strong association of nontumor anti-LGI1 (show LGI1 Proteins) encephalitis with HLA-DRB4.
HLA-DR4 is a susceptibility factor for the development of AIH. Impaired suppressive function of Tregs and reduced PD-1 (show PDCD1 Proteins) expression may result in spontaneous activation of key immune cell subsets, such as antigen-presenting cells and CD8 (show CD8A Proteins)(+) T effectors, facilitating the induction of AIH and persistent liver damage.
HLA-DRB4 affects type 1 diabetes risk and islet autoantibodies.
The study identifies a region of focus for B and T cell responses to IA-2 (show PTPRN Proteins) in HLA-DR4 diabetic patients that may explain HLA associations of IA-2 (show PTPRN Proteins) autoantibodies.
HLA-DR4 codes for susceptibility to RF+ polyarticular JIA with a six-fold risk.
The HLA- DR4 gene was clearly associated with susceptibility to rheumatoid arthritis.
There was a strong association of aspirin resistant thrombophilia with expression of HLA-DRB4 and HLA-DQA1 (show HLA-DQA2 Proteins).
Heterozygosity of HLA-DRB3 (show HLA-DRB3 Proteins)*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia.
Data indicate that invariant NKT (iNKT) cell-mediated cytokine secretion in staphylococcal enterotoxin B (SEB)-challenged HLA-DR4-transgenic mice was CD1d-independent.
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
DRB1 transplantation antigen
, HLA class II histocompatibility antigen, DR beta 4 chain
, MHC HLA DR-beta chain
, MHC class II antigen DRB4
, MHC class II antigen HLA-DR-beta
, MHC class2 antigen
, human leucocyte antigen DRB4
, leukocyte antigen