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anti-Human PKC delta Antibodies:
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Human Monoclonal PKC delta Primary Antibody for IF, IP - ABIN967943
Bell, Burns: Lipid activation of protein kinase C. in The Journal of biological chemistry 1991
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Human Monoclonal PKC delta Primary Antibody for IF, IP - ABIN967942
Blass, Kronfeld, Kazimirsky, Blumberg, Brodie: Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. in Molecular and cellular biology 2001
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Human Polyclonal PKC delta Primary Antibody for WB - ABIN2802039
Aris, Basta, Holmes, Ballas, Moomaw, Rankl, Blobel, Loomis, Burns: Molecular and biochemical characterization of a recombinant human PKC-delta family member. in Biochimica et biophysica acta 1993
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Human Polyclonal PKC delta Primary Antibody for IHC - ABIN966838
Sakamoto, Aschenbach, Hirshman, Goodyear: Akt signaling in skeletal muscle: regulation by exercise and passive stretch. in American journal of physiology. Endocrinology and metabolism 2003
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Human PKC delta Primary Antibody for IHC - ABIN966837
Zhang, Keane, Zhu, Sharma, Rozengurt, Strieter, Dubinett, Huang: Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis. in The Journal of biological chemistry 2004
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Human Monoclonal PKC delta Primary Antibody for IF, ELISA - ABIN562385
Chen, Nguyen, Shively: Role of calpain-9 and PKC-delta in the apoptotic mechanism of lumen formation in CEACAM1 transfected breast epithelial cells. in Experimental cell research 2010
Human Polyclonal PKC delta Primary Antibody for IHC, WB - ABIN362384
Van Kolen, Slegers: Atypical PKCzeta is involved in RhoA-dependent mitogenic signaling by the P2Y(12) receptor in C6 cells. in The FEBS journal 2006
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Findings unveil a negative role for PKC-delta in cell-cell adhesion through phosphorylation of E-cadherin (show CDH1 Antibodies).
ADP inhibits mesothelioma cell proliferation via PKC-delta/JNK (show MAPK8 Antibodies)/p21 (show CDKN1A Antibodies)/p27 (show PAK2 Antibodies) signaling.
PKCdelta, via MAPK (show MAPK1 Antibodies) pathway, is involved in the glycodelin (show PAEP Antibodies)-driven cell differentiation.
PKCdelta is a critical regulator of signaling mechanisms of neutrophil-endothelium interaction in acute inflammation. Inhibition of PKCdelta in human endothelial cells and neutrophils reduced chemoattractant-induced neutrophil migration across TNF-alpha (show TNF Antibodies)-activated endothelium, and reduced expression of E-selectin (show SELE Antibodies) and ICAM-1 (show ICAM1 Antibodies). Shear rate and vascular geometry regulate the impact of PKCdelta inhibition of neutrophil-endot...
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (show HCK Antibodies)-dependent activation of PKCdelta, which stimulates PKCgamma (show PRKCG Antibodies), resulting in translocation of phosphorylated p47(phox).
The interplay between intracellular progesterone receptor (show PGR Antibodies) and PRKCA (show PKCa Antibodies)-PRKCD plays a key role in migration and invasion of human glioblastoma cells.
Amphiregulin (show AREG Antibodies) enhances VEGF-A (show VEGFA Antibodies) production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR (show MLXIP Antibodies)-206 via FAK (show PTK2 Antibodies)/c-Src (show SRC Antibodies)/PKCdelta pathway.
In the present investigation, we demonstrated that miR486 is negatively associated with the expression of PKC-delta and could regulate the development of osteosarcoma. miR (show MLXIP Antibodies)-486 may be a potential target for the treatment of osteosarcoma
PKCdelta and PKCepsilon (show PRKCE Antibodies) work as a functional couple with opposite roles on thrombopoiesis, and the modulation of their balance strongly impacts platelet production.
These findings suggest that targeting Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) or Akt (show AKT1 Antibodies) pathways may increase the efficacy of taxane chemotherapy in advanced human prostate cancers that have lost PKCdelta expression.
Data suggest that the upregulation of mitochondrial respiratory chain proteins played a partial role in the protection of PKA/CREB (show CREB1 Antibodies) signaling.
HIF1a (show HIF1A Antibodies) transcriptional activity is stimulated by Protein kinase A-dependent phosphorylation
Generation of the Dnajb1 (show DNAJB1 Antibodies)-Prkaca (show PRKACA Antibodies) fusion gene in wild-type mice to be sufficient to initiate formation of tumors that have many features of human fibrolamellar hepatocellular carcinonma.
Data indicate a subpopulation of the CaV1.2 (show CACNA1C Antibodies) channel pore-forming subunit (alpha1C) within nanometer proximity of protein kinase A (PKA) at the sarcolemma of murine and human arterial myocytes.
S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP (show SCP2 Antibodies)), a form of synaptic plasticity that requires Cav1.2 (show CACNA1C Antibodies) and enhancement of its activity by the beta2-adrenergic receptor (show ADRB2 Antibodies) (beta2AR (show ADRB2 Antibodies))-cAMP-PKA cascade.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (show NRG1 Antibodies) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
spinal PKCdelta has a role in the development of chronic pain in SCD (show SCD Antibodies), which may become a potential target for pharmacological interventions
study identifies a new role of Dual-AKAP1 (show AKAP1 Antibodies) in regulating mitochondrial trafficking through Miro-2 (show RHOT2 Antibodies), and supports a model in which PINK1 (show PINK1 Antibodies) and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity
Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit)
K8/K18 (show KRT18 Antibodies)-dependent PKCdelta- and ASMase (show SMPD1 Antibodies)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 Antibodies) loss.
Report PRKCD-dependent regulation of bovine embryonic development, gene expression and post-hatching events.
investigation of signaling mechanism used by fibroblast growth factor-2 (FGF2 (show FGF2 Antibodies)) to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 (show FGF2 Antibodies) regulates IFNT production in trophoblasts by acting through PRKCD
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (show NOS3 Antibodies) post-translational modification
stimulation of bovine theca cells with lysophosphatidic acid leads to redistribution of protein kinase C delta from the cytosol to the perinuclear area and in the presence of LH, complete nuclear translocation of protein kinase C delta is induced
Protein kinase (show CDK7 Antibodies) Cdelta-dependent phosphorylation of syndecan-4 (show SDC4 Antibodies) regulates cell migration.
Activation of PKC (show PKC Antibodies) induces the translocation of Nrf2 (show NFE2L2 Antibodies) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
PKC-delta (show PRKCG Antibodies) mediates the apoptotic processes through ROS (show ROS1 Antibodies)-dependent caspase-3 (show CASP3 Antibodies) activation
Here, substitution studies on peptides correlating to the C1B domain in PKC gamma (show PRKCG Antibodies) show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
protein kinase C delta VIII
, protein kinase C delta type
, tyrosine-protein kinase PRKCD
, protein kinase C delta variant IX
, protein kinase C, delta IV
, protein kinase C, delta V
, protein kinase C[d]
, protein kinase-delta2
, protein kinase C, delta
, protein kinase C delta type-like
, PKA C-alpha
, cAMP-dependent protein kinase catalytic subunit alpha
, sperm cAMP-dependent protein kinase catalytic subunit
, protein kinase C delta
, protein kinase C gamma type