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TEAD2 Products

(TEA Domain Family Member 2 (TEAD2))

Categories

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

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Featured TEAD2 Categories

TEAD2 Antibodies

High quality antibodies with extensive validation data.

TEAD2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TEAD2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application IC, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN7303454
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN570968
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application DB, ICC
Validations
  • (2)
Cat. No. ABIN931123
Quantity 100 μg
Datasheet Datasheet

Recommended TEAD2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6207953
Quantity 96 tests
Datasheet Datasheet

Recommended TEAD2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134185
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095878
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1322441
Quantity 2 μg
Datasheet Datasheet

Latest Publications for our TEAD2 products

Mao, Chen, Xu, Fujita, Motoki, Sasabe, Homma, Murata, Tagawa, Tamura, Kaye, Finkbeiner, Blandino, Sudol, Okazawa: "Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology." in: Human molecular genetics, (2016) (PubMed).

Gadi, Jung, Lee, Jami, Ruthala, Kim, Cho, Jung, Kim, Lim: "The transcription factor protein Sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors." in: The Journal of biological chemistry, Vol. 288, Issue 35, pp. 25400-13, (2013) (PubMed).

Sawada, Kiyonari, Ukita, Nishioka, Imuta, Sasaki: "Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival." in: Molecular and cellular biology, Vol. 28, Issue 10, pp. 3177-89, (2008) (PubMed).

Synonyms and alternative names related to TEAD2

TEA domain transcription factor 2 (TEAD2), TEA domain family member 2 (Tead2), TEA domain transcription factor 2 (Tead2), Etdf, ETF, TEAD-2, TEAD2, TEF-4, TEF4

Protein level used designations for TEAD2

  • TEA domain family member 2
  • transcriptional enhancer factor TEF-4-like
  • transcriptional enhancer factor TEF-4
  • ETEF-1
  • embryonic TEA domain-containing factor
  • Embryonic TEA domain containing factor
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